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Tag: Spinal Discs

Disc hernia
In Aging Cell, researchers have published a potential method of ameliorating disc degeneration that focuses on the cells living in a low-oxygen environment within the discs. Living on low oxygen Yesterday, we discussed how an antioxidant compound was found to alleviate intervertebral disk degeneration (IVDD). This related paper focuses on a tissue that is already...
Lower back pain
In a recent paper, researchers from McGill University in Canada have investigated how a combination of two senolytics, RG-7112 and o-Vanillin, influences the intervertebral disc cells of back pain patients [1]. Back pain is a widespread issue An overwhelming majority of people, a full 80%, have suffered from back pain at some point in their...
Spinal degeneration
Researchers publishing in Aging have outlined a relationship between disc degeneration, macrophage polarization, inflammation, and sirtuins, demonstrating their effectiveness in a rat model of the disease. A crippling and painful disease Intervertebral disc degeneration (IDD) is a major cause of pain and disability [1], as it leads to the physical deterioration of the shock-absorbing discs...
Spinal disc
Partial cellular reprogramming using Yamanka factors has become increasingly prominent in the world of aging research. A new study suggests that transient exposure to the Yamanaka factors might be the solution to intervertebral disc degeneration [1]. Partial cellular reprogramming with Yamanaka factors We have talked previously about Yamanaka factors and how exposure to them can...
Spinal Disc Degeneration
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause of disability [1]. Age-related disease with early onset Conventional wisdom says that our spines just were not built to last for as long as humans...
Spinal degradation
Recent research out of Frontiers in Pharmacology has shown that a natural herbal compound reduces senescence and intervertebral disc degeneration in mice. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful...