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Tag: SIRT1

Running mouse
A team of researchers publishing in Cell Death & Disease has found that the age-related decline of mitochondrial calcium uptake family member 3 (MICU3), a regulator of mitochondrial function, is associated with sarcopenia, the aging-associated loss of muscle. Why mitochondria control their calcium uptake The calcium ion, Ca2+, is vital in mitochondrial metabolism and interacts...
Small meal
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their exhaustion The reviewers began by discussing stem cell exhaustion, a hallmark of aging and a common concern of aging research that we have covered extensively....
Diagram of NADH
What is NAD+? Nicotinamide adenine dinucleotide (NAD+) is a key coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base, and the other contains nicotinamide. NAD+ is essential for life, one of the most versatile molecules...
Red wine
A human study on the popular supplement resveratrol on heart failure patients has been published, and the results are significant. What is resveratrol? Resveratrol, is a naturally occurring stilbenoid, a type of phenol that is present in various plants and foods, such as grapes, peanuts, cocoa, blueberries, raspberries, and cranberries. It is frequently mentioned as...
Autophagy
Genes in the sirtuin family are conserved across a wide range of species and are involved in cellular metabolism, immune response, and aging. SIRT1 is known to decline during aging, but the mechanisms involved in this process were not known. Now, an international team has clarified how SIRT1 is regulated during cellular senescence [1]. Why...
Today, we want to highlight a new study that used in silico analysis to look at the interaction between metformin and SIRT1 [1]. SIRT1 and metabolism Silent mating type information regulation 2 homolog (SIRT1) is a member of the sirtuin protein family, and studies suggest that human sirtuins act as intracellular regulatory proteins. Sirtuin 1...