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Tag: SIRT1

Diagram of NADH
What is NAD+? Nicotinamide adenine dinucleotide (NAD+) is a key coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base, and the other contains nicotinamide. NAD+ is essential for life, one of the most versatile molecules...
Red wine
A human study on the popular supplement resveratrol on heart failure patients has been published, and the results are significant. What is resveratrol? Resveratrol, is a naturally occurring stilbenoid, a type of phenol that is present in various plants and foods, such as grapes, peanuts, cocoa, blueberries, raspberries, and cranberries. It is frequently mentioned as...
Autophagy
Genes in the sirtuin family are conserved across a wide range of species and are involved in cellular metabolism, immune response, and aging. SIRT1 is known to decline during aging, but the mechanisms involved in this process were not known. Now, an international team has clarified how SIRT1 is regulated during cellular senescence [1]. Why...
Today, we want to highlight a new study that used in silico analysis to look at the interaction between metformin and SIRT1 [1]. SIRT1 and metabolism Silent mating type information regulation 2 homolog (SIRT1) is a member of the sirtuin protein family, and studies suggest that human sirtuins act as intracellular regulatory proteins. Sirtuin 1...
A team of Harvard Medical School scientists led by Dr. David Sinclair has successfully reversed the aging of blood vessels in a new study, and human trials are currently underway. The therapy restores blood vessel growth and muscle vitality and boosts exercise endurance in aging animals. Age-related muscle wastage is linked to vascular aging The...