April 07, 2020
Could therapies designed to remove senescent cells, which accumulate with age, potentially be used to treat asthma? The researchers of a recent review certainly believe this could be the case, and there is plenty of reason to think they could be right. Senescent cells and aging As we grow older, increasing amounts of our cells...
March 23, 2020
The researchers of a new review have examined the relationship between cellular senescence and bone marrow cancers, looking at how senescence can ultimately fuel cancer development and how malignant cells induce senescence [1]. Senescent cells and cancer As we get older, an increasing number of our cells enter into a state known as senescence, a...
March 19, 2020
A study published in Aging shows that not only do different cell types express different levels of the senescence markers p16 and p21, these markers increase, and occasionally decrease, at different rates. Senescence and its markers Senescent cells are known to be harmful in excess, as they do not support their tissues and excrete the...
February 21, 2020
Researchers have discovered that the powerhouses of our cells, the mitochondria, also play a role in triggering cells to enter senescence, a dormant state in which cells cease to divide and begin to shut down, ready to die. Mitochondria trigger cytoplasmic chromatin and inflammation The new study shows that the mitochondria in each cell communicate...
February 20, 2020
King's College in London, UK has been awarded a grant to investigate the role of senescent cells, which accumulate as we age, in the context of the heart and how using a therapy to remove them influences its ability to recover from injury. What are senescent cells? As you age, increasing numbers of your cells...
February 11, 2020
At the recent Longevity Therapeutics Conference in San Francisco, we had the chance to interview Lewis Gruber of SIWA Therapeutics and discuss his company's senotherapeutic approach to cancer and senescent cells. He was accompanied by his wife, Misty, who is the CFO of SIWA. Many of our readers are familiar with CAR-T immunotherapy, which has...
