Tag: Senescent cells

At the recent Longevity Therapeutics Conference in San Francisco, we had the chance to interview Lewis Gruber of SIWA Therapeutics and discuss his company's senotherapeutic approach to cancer and senescent cells. He was accompanied by his wife, Misty, who is the CFO of SIWA. Many of our readers are familiar with CAR-T immunotherapy, which has...

Let’s face it, getting older sucks, and not because of all the extra candles on the birthday cake. Getting cake and presents every year is great, but the loss of health and independence isn't a particularly good birthday present. (Wow, what'd I get this year? Just what I didn't want: sarcopenia and hearing loss!) Given...

Today, we will take a look at the popular supplement fisetin and see how it stacks up as a geroprotector. History of Fisetin Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its...

New research suggests that senolytic drugs, which remove harmful senescent cells that accumulate during aging, may be an effective therapy for glaucoma, a common age-related condition that leads to loss of vision. In the short term, inflammation serves a useful purpose, as it helps to spur the repair and regeneration of tissue and rallies the...

A new study sheds light on the accumulation of senescent cells and suggests that therapies that remove them could be beneficial both immediately and in the long term for human health and longevity. Normally, as cells become damaged beyond repair, exhausted, and no longer able to replicate, they are removed from the body via a...

A new paper on senescent cells and aging brings together the current knowledge on the subject and presents it in a handy review format. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they...