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Tag: Salk Institute

March 13, 2020
Today, we are going to take a look at the companies working on resetting cellular aging through a reprogramming approach that directly targets a core reason we age. Cellular reprogramming resets aging in cells As we age, our cells experience alterations to their epigenetic markers, and this, in turn, changes gene expression; this process is...
September 30, 2019
At our 2019 Ending Age-related Diseases conference in New York City, we had the pleasure of speaking with Dr. Michael West, the CEO of AgeX Therapeutics. Dr. West can rightfully be called a pioneer in his field with a substantial background in biomedical and biotechnology corporations. After completing his PhD at Baylor College of Medicine,...
October 23, 2018
Researchers from the Salk Institute have discovered that a protein called Chrdl1, secreted by astrocytes, is responsible for driving synapse maturation and limiting brain plasticity later in life [1]. Abstract In the developing brain, immature synapses contain calcium-permeable AMPA glutamate receptors (AMPARs) that are subsequently replaced with GluA2-containing calcium-impermeable AMPARs as synapses stabilize and mature....
June 05, 2018
Thanks to a new technique, researchers from the Salk Institute's Gage laboratory have shown that impaired energy production might be a reason why human brains are susceptible to age-related diseases in the first place [1]. In particular, Salk scientists observed that induced neurons (iNs) obtained from fibroblasts of older individuals had dysfunctional mitochondria and therefore...
January 22, 2018
Novel therapeutic approaches may often require quite a bit of lateral thinking, as researchers at the Salk Institute have recently shown in a study presenting a novel method to interfere with cancer growth. The problem with cancer In a nutshell, the reason cancer is such an insidious enemy is that its cells divide uncontrollably, leading...