October 27, 2022
A recent study published in Molecules has tested multiple thiazole-based derivatives that appear to activate the sirtuin SIRT1 more than resveratrol [1]. Sirtuins Resveratrol, commonly found in grape skins and red wine, generated some of the initial interest in sirtuin activators after initial studies showing many therapeutic benefits, such as cancer prevention [2]. Combined with...
July 12, 2022
Researchers have shown that resveratrol reverses several features of ovarian aging in mice while activating most sirtuins and boosting mitochondrial health [1]. Ovaries age first In many mammals, including humans, ovarian aging is premature compared to other systems. The reasons for this accelerated loss of function are not entirely clear, but they are known to...
March 07, 2022
On this episode of Lifespan News, Ryan O'Shea revisits the ongoing controversy involving resveratrol and the widely known longevity enthusiast David Sinclair. Script In a recent episode of Lifespan News, we discussed a controversy surrounding resveratrol, and today, we’ll update you on the reaction to that video and how we’ll approach this going forward. Resveratrol...
February 25, 2022
Scientists have shown that resveratrol rescues erectile function in aged rats, most probably by activating SIRT1, and that it can work in synergy with the existing erectile dysfunction treatment tadalafil [1]. A molecule of discord Resveratrol, a plant-derived chemical of the polyphenol family, was once considered one of the most promising anti-aging molecules. David Sinclair’s...
February 21, 2022
On this episode of Lifespan News, Ryan O'Shea focuses on a recent controversy involving David Sinclair and the well-known supplement resveratrol. Script There’s been some controversy recently regarding resveratrol and the work of Dr. David Sinclair. In 2003, he published research on yeast in the journal Nature that said - “We show that the potent...
October 25, 2021
A team of researchers publishing in Aging have shown that resveratrol reduces inflammation and partially restores function in a rat model of spinal injury. In line with previous research This is far from the first study that aimed to use approaches associated with aging research in order to spur regeneration. For example, we have previously...
