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Tag: Proteomics

Prediction
In Nature Aging, researchers have published a method of predicting dementia over a decade before it actually occurs. Early detection was known to be possible It has been known that it is possible to observe early signs of brain deterioration years before dementia occurs [1]. However, actually performing accurate tests in a clinical setting has...
Handful of organs
In Nature, a team has published its research on using protein analysis to estimate the aging of specific organs. Aging is not all at once While the processes of aging affect every organ of every person, the rates at which these processes affect these organs can vary greatly in people [1] and mice [2]. Similar,...
Clockworks
Assisted by TruDiagnostic, a team of researchers has published a preprint paper in which -omics data has been used to create an epigenetic methylation clock. Why -omics? Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age....
Osteoblasts
Researchers publishing in Aging have uncovered some of the molecular mechanisms behind why mesenchymal stem cells (MSCs) do and don't differentiate into bone-building osteoblasts, unlocking a potential new approach to osteoporosis. A matter of cellular fate MSCs are downstream of pluripotent stem cells: they can differentiate into multiple cell types, but not every somatic cell...
Disagreeing clocks
A paper published in Aging goes into detail about the proteins and RNA pieces that increase and decrease with aging, suggesting a multiple-clock approach to biomarkers. Blood proteins change with age The researchers start out by discussing existing clocks based on such measurements as imaging [1] and epigenetic methylation [2], which is the most well-known...
Elderly Blood Draw
Published in GeroScience, a groundbreaking study from the renowned Conboy lab has confirmed that plasma dilution leads to systemic rejuvenation against multiple proteomic aspects of aging in human beings. Systemic molecular excess This paper takes the view that much of aging is driven by systemic molecular excess. Signaling molecules, antibodies, and toxins, which gradually accumulate...