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Tag: Partial Cellular Reprogramming

Powerful mixture
A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. Beyond OSKM This paper begins with a discussion of the four well-known Yamanaka reprogramming factors (OSKM) that cause cells to revert to a previous epigenetic state, citing previous...
Vittorio Sebastiano
Vittorio Sebastiano is an Associate Professor (Research) of Obstetrics and Gynecology at Stanford University and one of the most prominent scientists in the emerging field of cellular reprogramming. He is also co-founder and Scientific Advisory Board Chairman of Turn Biotechnologies, a cellular rejuvenation company based on the research done in Sebastiano’s Stanford lab. Turn recently...
Yuri Deigin Interview
In a recent press release, YouthBio Therapeutics announced that it has left stealth mode. YouthBio is a self-proclaimed longevity biotech company with a focus on developing gene therapies that reverse the epigenetic alterations that cause us to age. The company is hoping to reverse cellular aging in people through partial cellular reprogramming. This approach reverses...
Mouse Tumor
Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why can't we regrow limbs? Cellular reprogramming induces de-differentiation of somatic cells back into pluripotent stem cells: a 'factory reset' that erases cell-specific software and hence...
Genetic research
Scientists have shown that a single cycle of partial cellular reprogramming leads to various changes in the tissues, but about half of them gradually disappear after the treatment [1]. Permanent or transient? It has been known since 2006 that somatic cells can be reverted to a pluripotent stem cell-like state by overexpressing certain regulatory genes....
On Tuesday, March 29th, the Journal Club will be livestreamed to our Facebook page at 12:00 Eastern. Dr. Oliver Medvedik will be taking a look at a new paper showing that partial cellular reprogramming to reverse cellular aging is possible in normally aged mice. Previous studies demonstrated that the approach was possible in mice engineered...

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