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Tag: Partial Cellular Reprogramming

Genetic science
In Nature Communications, Ali Yücel and Vadim Gladyshev have published a review of the current state of the art in partial cellular reprogramming, detailing what this technology does and how it might be used safely. Affecting methylation directly Yamanaka Factors - Opportunities for RejuvenationDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and...
Epigenetic reprogramming
The authors of a recent review published in Ageing Research Reviews summarize the research on epigenetic reprogramming and its potential as a rejuvenation therapy [1]. Epigenetics in aging Aging leads to changes in the epigenome. Those changes can lead to alterations in gene regulation, affecting cellular homeostasis, and can play a role in age-associated phenotypes....
Glaucoma test
In a new study, scientists have achieved significant improvement of glaucoma in a mouse model via partial cellular reprogramming of retinal cells. However, it might take more than that to reverse other aspects of age-related vision loss [1]. The vision of restored vision The group that authored this paper, led by the prominent geroscientist Dr....
Skin up close
Scientists have found a way to reprogram fibroblasts without chemicals by culturing them on a surface with specific mechanical properties. Transplanted into aged skin, those cells boosted rejuvenation in a human tissue model [1]. We've all got skin in the game Skin aging might not be the deadliest part of organismal aging, but it certainly...
A team led by renowned Harvard geroscientists David Sinclair and Vadim Gladyshev has reported successful chemically induced partial cellular reprogramming in vitro. The researchers have also developed a novel cellular rejuvenation assay [1]. Smaller than proteins Complete cellular reprogramming using the Yamanaka factors was first accomplished more than ten years ago [2]. Those four proteins,...
Mouse DNA
A preprint published in bioRxiv by scientists working at Rejuvenate Bio has described how gene therapy that allows for OSKM expression can be used to increase the lifespans of mice. A new handle on old problems The researchers begin this study with a discussion of the known problems of aging research. They bring up the...