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Tag: NF-kB

Research mouse
April 14, 2021
A new study in Molecular Cell has shown that the benefits of hypoxia may be derived from a suppression of the inflammatory SASP. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially...
January 04, 2021
The results of a recent study suggest that fisetin appears to reduce the development of bleomycin-induced pulmonary fibrosis [1]. Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its basic chemical characteristics were...
Irina and Michael Conboy
June 16, 2020
Back in 2005, Drs. Irina and Michael Conboy showed that joining the circulatory systems of young and old mice together in a procedure called parabiosis could rejuvenate aged tissues and reverse some aspects of aging in old mice. Following this discovery, many researchers concluded that there must be something special in young blood that was...
Broken gears
April 02, 2020
A new study published in Aging shows a clear link between the natural response to genomic damage and cellular senescence, illustrating a principal method by which the effects of a primary hallmark of aging flow downstream. An ATM you don't want to withdraw from When our DNA is damaged, the cell responds with signals, summoning...
August 23, 2018
Today, we wanted to draw your attention to a recent study showing an association between the accumulation of Tau proteins, which are misfolded proteins that typically indicate Alzheimer's disease, and senescent cells. The researchers also showed that Tau pathology was improved by the use of drugs that remove non-dividing senescent cells. Unfortunately, this journal paper...