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Tag: Neurodegenerative Diseases

Brain COVID
A new publication in Nature Aging has used organoids and model mice to discover that senolytics may be effective treatments for neurodegeneration caused by long COVID. A link between COVID-19 and cellular senescence Post-acute infection syndromes (PAISes) are caused by a variety of viral and bacterial infections. The PAIS specific to the COVID-causing SARS-CoV-2, "long...
Active cells
In a mouse model of Huntington’s disease, scientists showed that injected young healthy brain cells can outcompete and eventually replace old, diseased ones. The results might be relevant for other neurodegenerative diseases [1]. When neurons’ helpers fail The non-neuronal cells in the brain are collectively known as glia. This category includes astrocytes, which nourish neurons...
A review article published in European Neuropsychopharmacology has described how and why psychedelic compounds may be useful in treating neurodegenerative diseases such as Alzheimer's. A question of neuroplasticity BrainThe brain is perhaps the most important organ in the body. While many organs are critical to our survival, the brain contains the self. It is responsible...
Obese and healthy mouse
Research published in Immunity & Ageing has shown that obesity has significant, aging-associated effects on behavior and immunity in the brains of mice. Known effects on humans and mice The researchers introduce this study by discussing human studies. It is well known that obesity is a risk factor for severe metabolic disorders, such as diabetes...
16 Hour Fast
Scientists from Singapore have found that intermittent fasting alleviates damage incurred by chronic cerebral hypoperfusion, the impaired blood flow to the brain that is thought to be a cause of age-related dementia [1]. Why intermittent fasting? Back in the early days of geroscience, caloric restriction was the first intervention to substantially increase lifespan in lab...
Common Aggregate
Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related neurological disorders. Three classes of pathology, one protein fragment The authors of this study list three different classes of neurodegenerative protein disorders: TDP-43 proteinopathies, such...