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Tag: Neurodegenerative diseases

August 04, 2020
A group of scientists have shown that the SIRT2 protein increases the accumulation of amyloid beta, a known marker of Alzheimer's disease (AD), in the brains of mice. They propose a mechanism underlying this phenomenon and demonstrate that inhibiting SIRT2 ameliorates AD-associated cognitive decline in mice [1]. AD is one of the most devastating age-related...
July 29, 2020
Japanese researchers led by Professor Akiyoshi Saitoh from the Tokyo University of Science have published new research that explores the potential of oxytocin as a therapy to combat cognitive disorders such as Alzheimer's disease. Oxytocin is often called the love hormone, given its role in the reproductive system and its role in creating feelings such...
January 20, 2020
Scientists at Scripps Research have developed a new screening platform that has allowed them to identify a new set of compounds that appear to have a potent protective effect on the mitochondria of brain cells, helping these cells to defend against the kinds of stresses encountered during Alzheimer's disease and other neurodegenerative conditions. Improved screening...
November 22, 2019
A recent study published in Cell Stem Cell shows that fasting and metformin are effective in a mouse model of demyelination, which is caused in humans by such disorders as multiple sclerosis. Myelin, demyelination, and remyelination Myelin, a substance rich in beneficial proteins and fats, is an insulator and protector of nerve cells and helps...
August 27, 2019
In a recent study, a team from the Neurobiota Research Center in Korea has discovered that reducing gut dysbiosis partially alleviates the cognitive impairment associated with Alzheimer's disease. This may seem puzzling, as the gut and the brain are separate and relatively distant organs, but this research makes sense in the context of chronic inflammation....
July 19, 2019
In a recent study, a group of researchers from Hebrew University-Hadassah Medical School, Feinberg School of Medicine, and Tel Aviv University examined astrocytes in mice and found that these cells exhibited a senescent phenotype that led to neurodegeneration and neurotoxicity [1]. Age-dependent increase in senescent astrocytes adjacent to Aβ plaques Cellular senescence, discovered in 1961...