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Tag: Neurodegenerative Diseases

Common Aggregate
Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related neurological disorders. Three classes of pathology, one protein fragment The authors of this study list three different classes of neurodegenerative protein disorders: TDP-43 proteinopathies, such...
Running mouse
Publishing in GeroScience, a team of Oklahoma City researchers has found that a nitrone compound with a low molecular weight, OKN-007, maintains motor neuron functionality in the spinal cords of aging mice. Prior research OKN-007 is not new in the literature. This is a nitrone compound, which refers to a specific functional group in organic...
Neuron Connections
Researchers have identified an important mechanism of neurodegeneration that may be useful in treating age-related diseases such as Alzheimer’s and dementia [1]. These neurons must die Age-related neurodegenerative diseases, including Parkinson’s and Alzheimer’s, have become more prevalent mostly because of the successes of modern medicine. Today, more people become old enough to fall prey to...
Rat in maze
Researchers from Hebei Medical University in China have found that testosterone supplementation ameliorates age-related brain dysfunction in male rats. A focus on mitochondria Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause increasing levels of...
Neurons
A new study shows that functional deterioration of the nervous system contributes to late-life mortality and identifies a related bloodborne biomarker for all-cause mortality [1]. Neurofilament light chain (NfL) is a structural protein found in nerve cells. The nervous system has been implicated in aging and longevity, so the fact that NfL can be detected...
Mouse facing camera
A group of scientists have shown that the SIRT2 protein increases the accumulation of amyloid beta, a known marker of Alzheimer's disease (AD), in the brains of mice. They propose a mechanism underlying this phenomenon and demonstrate that inhibiting SIRT2 ameliorates AD-associated cognitive decline in mice [1]. AD is one of the most devastating age-related...