Tag: Mitochondrial Dysfunction

A recent study saw researchers associated with Cellvie demonstrate significant improvements to mitochondria and muscle function in aged mice by injecting additional mitochondria [1]. Mitochondrial dysfunction is a reason we age Why We Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species...

In Aging Cell, researchers have published evidence that downregulating a key aspect of lipid metabolism harms mitochondrial function, but only in cells taken from younger people. Fat regulation at the cellular level Perilipins (PLINs) are proteins that regulate the use of fats (lipids) within cells. This paper focuses on PLIN2, which has previously been investigated...

Scientists have tested a novel method of providing cells with healthy mitochondria to fight Parkinson’s disease [1]. Replacing damaged mitochondria Parkinson’s disease is the second-most prevalent neurodegenerative disorder, and it affects 10 million people worldwide. The disease is age-related, as its prevalence rises rapidly in people older than 65, although some people are diagnosed much...

The Journal Club is back for one final time this year! Dr. Oliver Medvedik will return on December 15th at 12:00 Eastern on the Lifespan.io Facebook page to review the recent paper "A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan". Join us and find out how researchers are boosting...

Publishing in Ageing Research Reviews, a team of researchers including Vera Gorbunova has described how a class of drugs originally used to treat HIV might be used to affect some of the hallmarks of aging. Inhibiting DNA changes DNA transcription, which transfers DNA code into the RNA that cells use to make proteins, can also...

In a review published in Nature, researchers have explained how and why cells transfer mitochondria to one another, proposing that this transfer allows organisms to be more resilient against energy deficiencies. A relatively recent discovery It was not until 2006 when a team of researchers realized that mitochondria were not restricted to their cellular environments, as...