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Tag: Mitochondrial Dysfunction

The Journal Club is a monthly livestream hosted by Dr. Oliver Medvedik which covers the latest aging research papers.
The Journal Club is back for one final time this year! Dr. Oliver Medvedik will return on December 15th at 12:00 Eastern on the Lifespan.io Facebook page to review the recent paper "A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan". Join us and find out how researchers are boosting...
Genetic damage
Publishing in Ageing Research Reviews, a team of researchers including Vera Gorbunova has described how a class of drugs originally used to treat HIV might be used to affect some of the hallmarks of aging. Inhibiting DNA changes DNA transcription, which transfers DNA code into the RNA that cells use to make proteins, can also...
Gift giving
In a review published in Nature, researchers have explained how and why cells transfer mitochondria to one another, proposing that this transfer allows organisms to be more resilient against energy deficiencies. A relatively recent discovery It was not until 2006 when a team of researchers realized that mitochondria were not restricted to their cellular environments, as...
Capillaries
Researchers publishing in GeroScience have discovered the molecular mechanisms through which fibrinogen, a protein that increases with aging, causes toxic compounds to more easily leak into the brain. The deteriorating blood-brain barrier In the brain, the microvessels (MVs) that are responsible for carrying blood to neurons and other cells provide careful filtration, both from infectious...
Resveratrol foods
According to a review published in Food Science and Human Wellness, resveratrol has a positive impact on mitochondrial dysfunction, one of the hallmarks of aging. A hallmark with downstream consequences Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that...
SENS Mitomouse 2
Financed by Lifespan.io's crowdfunding efforts, SENS Research Foundation has engaged in fruitful research into ways of dealing with mitochondrial dysfunction, the gradual loss of function of our cells' power plants. Here, the organization reports its successes in handling this aspect of aging. The cellular machinery and higher-level structures of our bodies inevitably damage themselves as...