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Tag: Mitochondrial Dysfunction

A depiction of NAD on a black background
February 05, 2021
Aging is accompanied by the loss of proteostasis, the accumulation of misfolded proteins and their amyloid aggregates, and mitochondrial dysfunction, which is partially characterized by the loss of mitochondrial homeostasis, the delicate balance that mitochondria need in order to produce energy without polluting the body with excessive amounts of free radicals. The hallmarks of aging...
Cellvie's corporate logo
January 26, 2021
The mitochondria are an important target in aging, as their age-related dysfunction is thought to be a reason we age. These tiny power stations living in our cells do a wonderful job producing energy and keeping us alive, but, as we age, they become increasingly dysfunctional and that supports the onset of various age-related diseases....
Lab rat and flasks
January 25, 2021
Glucosamine is a polysaccharide that naturally occurs in cartilaginous joint tissues and is involved in protein and lipid synthesis. Glucosamine is also present in other tissues, such as skin, nails, bones, and ligaments. Synovial fluid contains glucosamine and occupies the space between joints, helping to reduce the friction of joint surfaces. Glucosamine is commonly taken...
A picture of the Alpha-ketoglutarate molecule
January 18, 2021
Alpha-ketoglutarate (AKG) is a popular dietary and sports supplement frequently used in the bodybuilding world, but interest in this molecule has more recently reached the aging research field for its potential to slow down aging. AKG is a naturally occurring endogenous intermediary metabolite, which means that our own bodies create it, and is part of...
Image of an oocyte
September 24, 2020
According to new research, mutations accumulate in the mitochondrial DNA of egg cells, leading to changes in cellular metabolism, which result in reduced fertility. The study also showed that NMN treatment can restore the metabolic balance in aging mouse oocytes, rescuing fertility. Defective eggs Although malfunctioning of mitochondria and the accumulation of mutations in mitochondrial...
NADH molecule
September 14, 2020
This is part 2 of a series focused on the age-related decline of NAD+; if you have not read the previous part, you can find it here. Today, we are continuing our look at some of the evidence for the age-related decline of NAD+ in humans and some of the likely reasons why this happens....