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Tag: Mitochondrial Dysfunction

Nematode
A study published in Redox Biology has reported that the upregulation of thioredoxin, a fundamental part of mitochondrial defense against reactive oxygen species, is associated with longevity in mutant C. elegans worms. Free radicals, revisited Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and...
Seniors walking
Researchers publishing in Aging Cell have shown a relationship between mitochondrial dysfunction and mobility decline in older adults. A changing longitudinal study Since 1958, a team of researchers from the National Institute on Aging Intramural Research program has been conducting the Baltimore Longitudinal Study of Aging (BLSA). The BLSA, which has been used for other...
Pueraria
Publishing in Aging, a team of researchers has discovered how puerarin, an extract of kudzu, ameliorates chronic obstructive pulmonary disorder (COPD) signs in cellular cultures by limiting mitophagy: the consumption of mitochondria by cells. When autophagy isn't a good thing Mitophagy is a subset of autophagy, the consumption of any organelle by a cell. This...
Colorful mitochondria
Publishing in Aging, a group of Korean researchers has discovered a compound that affects the way our mitochondria process energy, ameliorating cellular senescence. A deep dive into biochemistry Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...
Heart and veins
The latest research published in the Journal of Anatomy found that spermidine alters the morphology of mitochondria in aged mouse heart tissue [1]. Mitochondrial dysfunction in the aging heart Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm...
Running mouse
A team of researchers publishing in Cell Death & Disease has found that the age-related decline of mitochondrial calcium uptake family member 3 (MICU3), a regulator of mitochondrial function, is associated with sarcopenia, the aging-associated loss of muscle. Why mitochondria control their calcium uptake The calcium ion, Ca2+, is vital in mitochondrial metabolism and interacts...