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Tag: Mitochondrial Dysfunction

Microplastics
A paper published in Environmental Science and Technology has described some of the effects of nanoplastics on human liver and lung cells [1]. Microplastics and nanoplastics Plastics in the environment are gradually broken down by sunlight, grinding processes, and biological activities into smaller and smaller pieces [2]. These are the infamous microplastics, but when they...
Dividing cell
Researchers publishing in Cell Stem Cell have found that the mitochondrial protein OPA1 is an integral, regulatory part of muscle stem cell activation, the process by which muscle stem cells proliferate and become active muscle tissue (myogenesis) [1]. Another piece of the puzzle We have recently reported on the effects of mitochondrial fusion and fission...
Smooth muscle
A paper published in Cell Stem Cell has detailed how mitochondrial division is critical to the ability of muscle stem cells to regenerate damaged tissue [1]. Waiting until needed This paper begins with a discussion of quiescent muscle stem cells, which are held in reserve until injury causes them to form new somatic muscle cells,...
Genes computer
Publishing in GeroScience, a team of researchers that included Nir Barzilai and Matt Kaeberlein examined genes that may affect both mitochondria and lifespan [1]. From the mitochondria to the nucleus Over time, evolution has moved mitochondrial DNA from the individual mitochondria to the nucleus, where they are better protected. SENS Research Foundation, in conjunction with...
Sophora Japonica
Researchers publishing in Journal of Biomedical Science have concluded that hesperetin, a compound found in various herbs, improves longevity in mice by promoting the expression of the pro-longevity gene Cisd2. Mitochondria and Cisd2 This paper begins with an explanation of mitochondrial dysfunction, one of the hallmarks of aging, and the function of Cisd2. Previous research...
Standing mouse
Publishing in Aging, a team of Spanish researchers has found that changing the mitochondria of standard Black 6 mice leads to marked improvements in joint health. Conplastic mice The Black 6 mouse is well-known in research as a standard in the industry. However, it is not nearly a perfect mouse in terms of ability or...

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