Tag: Mitochondrial Dysfunction

Financed by Lifespan.io's crowdfunding efforts, SENS Research Foundation has engaged in fruitful research into ways of dealing with mitochondrial dysfunction, the gradual loss of function of our cells' power plants. Here, the organization reports its successes in handling this aspect of aging. The cellular machinery and higher-level structures of our bodies inevitably damage themselves as...

Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn't work Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause...

A paper published today in Nature Cardiovascular Research has explained a relationship between dilated cardiac myopathy (DCM), epigenetic dysregulation, NAD+, and the epigenetic regulatory molecule Kdm8. A gradual decline of ability DCM occurs when the left ventricle of the heart becomes enlarged and loses its ability to pump enough blood. The heart muscle gradually thins,...

In a new study published in Free Radical Biology and Medicine, researchers have identified a link between mitochondrial function and the vulnerability of specific brain regions to age-associated neurodegeneration [1]. Brain region-specific vulnerability It is well-known that the human brain is heterogeneous in terms of structure and function. The prefrontal cortex is responsible for complex...

Researchers publishing in BMC Medicine have found that there is a relationship between biomarkers of aging and measurements of health and mental well-being [1]. "Healthy lifestyle" is not just a phrase It is very well known that unhealthy behaviors are strongly linked to adverse health outcomes. For example, alcoholism is a significant risk factor for...

A paper published in Environmental Science and Technology has described some of the effects of nanoplastics on human liver and lung cells [1]. Microplastics and nanoplastics Plastics in the environment are gradually broken down by sunlight, grinding processes, and biological activities into smaller and smaller pieces [2]. These are the infamous microplastics, but when they...