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Tag: Mitochondrial dysfunction

July 14, 2020
Researchers have developed what can be described as the first precision gene editing tool for mitochondrial DNA (mtDNA). This new tool is different from the well-known CRISPR/Cas9 method of gene editing and should make the study of mitochondrial biology and mitochondrial diseases easier. This new discovery is a game changer Prior to this, creating mouse...
June 11, 2020
Researchers have discovered that a lack of NAD+ is responsible for mitochondrial dysfunction in egg cells (oocytes), leading to decreased fertility with age. Mitochondria in oocytes Given how much it must divide to create a human being, the oocyte is the largest cell in the human body, and it contains far more mitochondria than any...
June 08, 2020
Researchers have concluded a human trial using niacin, a very old vitamin discovered over 80 years ago, and have shown that it can increase the presence of an energy compound essential to cellular function. Niacin and NAD+ Niacin is a form of water-soluble vitamin B3 and has been known since American biochemist Conrad Elvehjem identified...
May 28, 2020
Researchers from the Laboratory for Cell Function Dynamics in Japan have developed a new method for detecting mitophagy, the process of recycling damaged mitochondria. The Necessity of Mitophagy Our mitochondria are the powerhouses of our cells, turning the food we eat into ATP, the form of chemical energy that our cells use. However, over time,...
May 07, 2020
Our mitochondria, which originated from ancient bacteria, act like batteries, giving our cells the energy they need to live. In this informative episode of X10, Veera explains what happens to these organelles with aging and what we can do about it...
April 28, 2020
A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major factor in the age-related decline of cognitive and motor functions, this discovery presents exciting new possibilities for longevity research. Neurovascular coupling While the human brain...