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Tag: Inflammaging

September 25, 2020
Dr. Oliver Medvedik and the Journal Club will be returning on September 29th at 13:00 EDT live on our Facebook page. The topic for this month is going to be a new study that implicates an innate immune inflammatory protein in disease progression using mouse models. Innate immunity is associated with Alzheimer's disease, but the influence...
September 03, 2020
A research team led by Dr. Brian Kennedy has shown that administration of alpha-ketoglutarate (AKG), a natural metabolite in the citric acid cycle, improves both lifespan and healthspan in middle-aged mice. Modest increase in lifespan For this study, the researchers administered a calcium salt of AKG, CaAKG, to 18-month-old male and female Black 6 mice,...
August 24, 2020
A new review takes a look at the association between the decline of the immune system and the development and course of age-related diseases. Our immune system is the ultimate defense against invading pathogens and unwanted waste, and its efficient operation is critical to the healthy function of every tissue in the body. We have...
August 14, 2020
A novel treatment that inhibits the activity of the Cdc42 protein has been found to extend the lifespan of aged mice, most likely through epigenetic changes and regulation of inflammatory cytokines. Cdc42 is linked with lifespan Cdc42 is a RhoGTPase, a kind of signaling protein involved in a variety of processes in eukaryotic cells. It...
July 08, 2020
Frailty and the decline of the immune system are two typical features of aging, but new research shows that both can be halted and even somewhat reversed using a novel cell-based therapy. Frailty and immunosenescence Frailty is something that frequently affects older people, and it ultimately results in the loss of independence and quality of...
July 02, 2020
In this informative episode of X10, Nicola discusses how our cells communicate with each other and how this communication network is disrupted with aging, causing systemic inflammation and other issues.