January 04, 2021
The results of a recent study suggest that fisetin appears to reduce the development of bleomycin-induced pulmonary fibrosis [1]. Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its basic chemical characteristics were...
December 23, 2020
A new article published in Aging and Disease has taken a look at what two stem cell-activating growth factors can do in aged mice with Alzheimer's-like pathology. Alzheimer's disease (AD) is perhaps the most age-related of all age-related diseases. Perhaps not coincidentally, it has also been the most stubborn disease to develop treatments for. One...
September 25, 2020
Dr. Oliver Medvedik and the Journal Club will be returning on September 30th at 1:00 PM EDT live on our Facebook page. The topic for this month is going to be a new study that implicates an innate immune inflammatory protein in disease progression using mouse models. Innate immunity is associated with Alzheimer's disease, but...
September 03, 2020
A research team led by Dr. Brian Kennedy has shown that administration of alpha-ketoglutarate (AKG), a natural metabolite in the citric acid cycle, improves both lifespan and healthspan in middle-aged mice. Modest increase in lifespan For this study, the researchers administered a calcium salt of AKG, CaAKG, to 18-month-old male and female Black 6 mice,...
August 24, 2020
A new review takes a look at the association between the decline of the immune system and the development and course of age-related diseases. Our immune system is the ultimate defense against invading pathogens and unwanted waste, and its efficient operation is critical to the healthy function of every tissue in the body. We have...
August 14, 2020
A novel treatment that inhibits the activity of the Cdc42 protein has been found to extend the lifespan of aged mice, most likely through epigenetic changes and regulation of inflammatory cytokines. Cdc42 is linked with lifespan Cdc42 is a RhoGTPase, a kind of signaling protein involved in a variety of processes in eukaryotic cells. It...
