July 08, 2020
Frailty and the decline of the immune system are two typical features of aging, but new research shows that both can be halted and even somewhat reversed using a novel cell-based therapy. Frailty and immunosenescence Frailty is something that frequently affects older people, and it ultimately results in the loss of independence and quality of...
July 02, 2020
In this informative episode of X10, Nicola discusses how our cells communicate with each other and how this communication network is disrupted with aging, causing systemic inflammation and other issues.
June 29, 2020
Researchers have published a new study suggesting that some of the inflammatory signals secreted by senescent cells could be used as a biomarker to measure aging and health. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the...
May 20, 2020
Researchers have demonstrated that age-related cognitive impairment and inflammation can be caused in young rats simply by giving them gut microbe populations from the guts of aged rats. The gut microbiome The microbiome describes the varied community of bacteria, archaea, eukarya, and viruses that inhabit our gut. The four bacterial phyla of Firmicutes, Bacteroidetes, Proteobacteria,...
May 14, 2020
A recent study published in Cell Metabolism has shown that metformin, a drug that has been previously shown to be effective against some aspects of aging, ameliorates inflammaging by promoting autophagy, the cellular recycling of damaged components. Mitochondrial dysfunction, autophagy, and TH17 Mitochondrial dysfunction is one of the hallmarks of aging, the root causes that...
April 15, 2020
Researchers have found that a protein called TIM-4 is essential to macrophages' ability to clean up cellular debris and that p38 MAPK, a protein that increases due to aging, inhibits TIM-4. Inflammaging and immunosenescence Aging is the primary risk factor for a myriad of chronic age-related diseases, including heart disease, Parkinson's, Alzheimer's, and cancer. As...
