April 02, 2020
A new study published in Aging shows a clear link between the natural response to genomic damage and cellular senescence, illustrating a principal method by which the effects of a primary hallmark of aging flow downstream. An ATM you don't want to withdraw from When our DNA is damaged, the cell responds with signals, summoning...
March 06, 2020
New research suggests that the very immune cells that protect our brain can eventually start attacking it due to chronic systemic inflammation, something that is typically present in older people. The blood-brain barrier The blood-brain barrier (BBB) surrounds most of the blood vessels in the brain and forms a protective barrier between the bloodstream and...
February 19, 2020
Researchers from Berkeley have established that SIRT2 prevents overactivation of the NLRP3 inflammasome through deacetylation. Targeting this pathway can possibly reduce or even reverse age-related chronic inflammation and insulin resistance. What are sirtuins? Sirtuins are a family of proteins that have long been a target of longevity research [1]. Sirtuins probably descend from some of...
January 06, 2020
New research suggests that senolytic drugs, which remove harmful senescent cells that accumulate during aging, may be an effective therapy for glaucoma, a common age-related condition that leads to loss of vision. In the short term, inflammation serves a useful purpose, as it helps to spur the repair and regeneration of tissue and rallies the...
December 11, 2019
A new paper on senescent cells and aging brings together the current knowledge on the subject and presents it in a handy review format. What are senescent cells? As you age, increasing numbers of your cells enter into a state known as senescence. Senescent cells do not divide or support the tissues of which they...
August 27, 2019
In a recent study, a team from the Neurobiota Research Center in Korea has discovered that reducing gut dysbiosis partially alleviates the cognitive impairment associated with Alzheimer's disease. This may seem puzzling, as the gut and the brain are separate and relatively distant organs, but this research makes sense in the context of chronic inflammation....
