Tag: Inflammaging

Found in many fruits and vegetables, quercetin may have some potential in the context of aging. Here, we take a look at this natural antioxidant and popular dietary supplement. What is quercetin? Quercetin is a natural flavonoid, which makes it part of a large family of water-soluble plant compounds. Flavonoids are not created by the...

A review published in Frontiers in Cell and Developmental Biology has explained how DNA damage and its accompanying immune response lead to changes in the microenvironment of stem cells, causing a decline in their function. Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly...

Publishing in Science Advances, a team of researchers has described how a scaffold containing genetically engineered induced pluripotent stem cells (iPSCs) can reduce symptoms in a mouse model of rheumatoid arthritis. The advantage over current drugs Rheumatoid arthritis (RA) is currently treated through drugs that often suppress the immune system as a side effect [1]....

A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have previously discussed the NLRP3 inflammasome, which releases inflammatory cytokines upon exposure to irritants [1], including reactive oxygen species (ROS) [2]. The researchers hypothesized that ROS,...

Researchers, publishing in the journal Aging, have discovered that a protein called hedgehog alleviates the tissue-specific, age-related inflammation of the microglia, the maintenance cells of the brain. The aging differences between tissue types To begin this research, the team first performed a gene expression analysis on four different types of murine macrophages: bone marrow-derived macrophages...

Epigenetic clocks have become a mainstay of longevity research over the past few years, with new clocks regularly being established for different species and tissues as well as promising research that uses and builds on these clocks. An international research team has recently created a different kind of clock, an inflammatory aging clock that predicts...