Tag: Inflammaging

A team of researchers has waded into a controversial and contradictory area of study, publishing information on the link between obesity and an inflammatory molecule that increases with aging. A context-dependent molecule What is Inflammaging? Chronic Inflammation and AgingOne of the aging processes consists of a chronic, smoldering background of inflammation that researchers call “inflammaging”.Read...

A new study suggests that depleting a subset of stem cells that overproduces myeloid cells can rescue age-related immunosenescence [1]. Thrown off balance Immunosenescence, the gradual decline in the immune system’s abilities, is one of the hallmarks of aging [2]. Moreover, many scientists view it as one of the most consequential processes of aging, as...

Researchers have described how specialized nanoparticles, which deliver rapamycin and the antioxidant astaxanthin, restore macrophage balance and reduce inflammation in a mouse model of osteoarthritis. A matter of polarization Inflammation is a critical part of arthritis. Previous studies have found that inflammation of the membranes in joints (synovitis) strongly contributes to osteoarthritis [1]; in fact,...

Researchers have described an intermediary state between senescent and young cells, the inflammatory problems caused by these cells, and how young cells secrete a protein that may alleviate these problems. What happens before senescence? Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support...

Publishing in Ageing Research Reviews, a team of researchers including Vera Gorbunova has described how a class of drugs originally used to treat HIV might be used to affect some of the hallmarks of aging. Inhibiting DNA changes DNA transcription, which transfers DNA code into the RNA that cells use to make proteins, can also...

In a paper published in Geroscience, researchers have developed a metric of systemic inflammation and used it to estimate mortality, finding that it performs better than epigenetic clocks. Evaluating a danger What is Inflammaging? Chronic Inflammation and AgingOne of the aging processes consists of a chronic, smoldering background of inflammation that researchers call “inflammaging”.Read More...