Tag: Glucose

A recent Molecular Metabolism paper dives into the differences between intermittent and chronic rapamycin treatment and its differential impact on male and female mice [1]. The dark side of rapamycin Rapamycin doesn’t need much introduction in the lifespan extension community. This mTOR inhibitor has been shown multiple times to extend lifespan in animal studies. Because...

A new study suggests that high protein intake leads to fat gain and worse metabolic outcomes, but some of these effects are blocked by resistance training. Low protein consumption resulted in less muscle gain but did not affect strength [1]. The protein debate One of the most hotly debated topics in nutritional science is how...

A new open-label, randomized, controlled study published in Cell showed that zero-calorie sweeteners are metabolically active and some might impair glycemic response in healthy adults [1]. What does “sugar-free” mean? The human brain is the main consumer of glucose in the body, and glucose availability is paramount for neurons to generate action potentials and release...

A team of Spanish researchers has examined how glucose imbalance leads to neurological disorders through the failure of adipocytokines. What are adipocytokines? These compounds' name seems a bit concerning: "adipo-" refers to fat, and a cytokine is a cellular signal most commonly known for being part of the deadly cytokine storm associated with severe immunological...

In recent years, there has been considerable interest in the naturally occurring molecule and dietary supplement nicotinamide mononucleotide (NMN) and its potential influence on aging. While there have been numerous animal studies suggesting that it may be useful in combating some age-related decline, there has been a lack of human data until now. In previous...

Somewhat serendipitously, Salk Institute researchers discovered that depleting the microbiomes of mice causes the animals to have lower levels of blood glucose as well as improved insulin sensitivity [1]. Abstract Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role of the gut microbiome in pathological conditions. However, unlike germ-free mice, the effects...