Tag: Gene Therapy

A paper published in Aging has detailed how gene therapy has been used to treat sarcopenia in wild-type mice, and the results are positive. A lack of effective treatments As expected with papers of this kind, the researchers begin by discussing frailty and sarcopenia, the age-related loss of muscle tissue that is associated with decreased...

Research published in Cell Stem Cell has described how previously unmodified animals have been given regenerative abilities akin to those of zebrafish, restoring their heart muscle after injury. A TREE of life This study is introduced with a discussion of gene therapy as a field, noting clinical approval for gene therapies against multiple genetic diseases...

A preprint published in bioRxiv by scientists working at Rejuvenate Bio has described how gene therapy that allows for OSKM expression can be used to increase the lifespans of mice. A new handle on old problems The researchers begin this study with a discussion of the known problems of aging research. They bring up the...

In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of life-extending gene therapies from science fiction to reality. Why a cytomegalovirus? The human cytomegalovirus (CMV) is widely known as an endemic virus that, while usually...

In a new study, mice transduced with a longevity-associated variant (LAV) of the BPIFB4 gene showed less immunosenescence and healthier vasculature [1]. The importance of having good genes Longevity-associated alleles prove that aging does not affect everyone equally. On average, centenarians and supercentenarians are more protected from age-related diseases than other people, and this protection...

In a study published in Genome Biology, researchers explain how they are working to make CRISPR less prone to large, accidental deletions of genetic material [1]. A previously unknown large problem While this seems counterintuitive, previous technology only allowed for the ready identification of deletions below 100 base pairs. New technology has allowed for larger...