April 23, 2021
The Journal Club hosted by Dr. Oliver Medvedik will return live to our Facebook Page at 12:00 EST on Tuesday 27th of April. This month we will be taking a look at a new paper and technique for the gene editing tool CRISPRcas9. The technique allows researchers to turn epigenetic methylation off and back on...
September 08, 2020
A group of researchers has used CRISPR to create energy-dissipating brown adipocytes (fat cells) from white preadipocytes. The new cells were then shown to alleviate obesity in mice [1]. Obesity: the nemesis of longevity Obesity is one of humanity’s deadliest enemies. It is a known comorbidity in a plethora of diseases, including age-related, such as...
March 31, 2020
Researchers have overcome a major limitation of the CRISPR-Cas9 gene editing system, which should allow previously inaccessible parts of the genome to be edited with ease. What is CRISPR-Cas9? Clustered regularly interspaced short palindromic repeats (CRISPR) is used in CRISPR-Cas9 and CRISPR-associated protein, a gene editing system that has created considerable excitement in the last...
November 25, 2019
A new study recently accepted by iScience has shown that a specific genetic alteration can selectively remove pluripotent stem cells from stem cell therapies in order to purify them for use in treatment. The cells we don't want As we age, our stem cells both decrease in number and become less efficient in replenishing somatic...
November 06, 2019
For the November episode of the Journal Club, Dr. Oliver Medvedik will be reviewing a new study from a team of researchers including Professor George Church. The study saw the deployment of a multiple target gene therapy focused on 3 known longevity genes delivered via an adeno-associated virus. The focus was on mitigating T2 diabetes, heart failure,...
April 22, 2019
On April 30th at 13:00 EST the Journal Club will be discussing the recent paper from the Salk Institute. The findings, published in the journal Nature Medicine, showcase a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome. This treatment provides an important insight into the molecular pathways...
