Tag: Gene Editing

The Journal Club returns on 25th July at 12:00 Eastern time to the Lifespan.io Facebook channel. Editing mitochondrial DNA (mtDNA) has long been a challenge and systems such as CRISPR, which make editing regular DNA faster and easier, are very difficult to use when it comes to mtDNA. This month we are going to take...

  Researchers have genetically engineered lettuce to produce human insulin. The resulting plant-based drug, which can be taken orally, was successfully tested in mice [1]. An epidemic and a costly drug Diabetes mellitus has reached epidemic proportions, affecting about half a billion people worldwide. This debilitating metabolic disease, which also exacerbates numerous processes of aging...

Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn't work Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause...

A preprint published in bioRxiv by scientists working at Rejuvenate Bio has described how gene therapy that allows for OSKM expression can be used to increase the lifespans of mice. A new handle on old problems The researchers begin this study with a discussion of the known problems of aging research. They bring up the...

In a new study published in Journal of Nanobiotechnology, researchers prevented muscle atrophy both in vitro and in vivo by delivering a CRISPR-Cas9 gene editing system packaged in engineered extracellular vesicles [1]. When just using it doesn’t quite cut it Aging is accompanied by the loss of muscle mass, also known as sarcopenia, which deteriorates...

In a new study published in GeroScience, researchers have shown that it is possible to significantly increase yeast lifespan by overexpressing genes highly conserved across various species [1]. Survival and aging The question of the effects of nature versus nurture, or programmed versus stochastic, sparks hot scientific debate in other fields as well as aging....