February 27, 2023
A team publishing in Human Genomics has developed a new model for analyzing epigenetic changes that uses nonlinear analysis. Current clocks are linear Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many different...
February 20, 2023
David Sinclair, PhD, esteemed molecular geneticist at Harvard, believes that aging is a disease that should be attacked at its roots. Furthermore, he believes if we are to make efficient and sensible use our medical resources, we must move away from the "whack-a-mole" approach to treating individual age-related diseases. In his first book, Lifespan: Why...
February 13, 2023
A paper published today in Nature Cardiovascular Research has explained a relationship between dilated cardiac myopathy (DCM), epigenetic dysregulation, NAD+, and the epigenetic regulatory molecule Kdm8. A gradual decline of ability DCM occurs when the left ventricle of the heart becomes enlarged and loses its ability to pump enough blood. The heart muscle gradually thins,...
January 20, 2023
Dr. Kara Fitzgerald's new book provides an evidence-based approach to diet and lifestyle that aims to reduce your biological age. Beginning with epigenetics Younger You offers a pragmatic and easily understood primer on the role of epigenetics and aging along with an exquisitely detailed plan for how to reduce your biological age. This book is...
January 13, 2023
Published in Cell, a new paper by David Sinclair and his team argues that epigenetic dysregulation in the form of information loss is a major driver of aging, but it can be reversed in vivo by partial cellular reprogramming. Genome or epigenome? Both genomic instability and epigenetic alterations are included in the Hallmarks of Aging...
December 21, 2022
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1]. Global changes It is well known that aging is accompanied by changes in the expression of many genes. Therefore, numerous studies have focused on identifying...
