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Tag: Epigenetic Alterations

Mice playing
A study published in Nature Communications has shown that an environment rich in stimuli changes the epigenetics of the mouse hippocampus, making the brains of aged mice more like those of young mice [1]. What is an enriched environment? For mice, enriched environments (ENRs) are "large cages equipped with frequently rearranged toys, providing physical, cognitive,...
Sheep
Researchers have shown that castration makes male sheep live longer, and they’ve also used genomic data to get a basic understanding of the mechanism behind this longevity [1]. While castration is unlikely to be part of a life extension therapy, unraveling its effect on lifespan will help flesh out the link between sex hormones and...
Chromatin and histones
Researchers have demonstrated that rapamycin, a drug that has long been believed to slow down aging, changes the way DNA is stored inside cells to support gut health and longevity [1]. This improvement to DNA storage has been observed in both fruit flies and mice in the lab, and the researchers believe that those benefits...
Elderly twins
Chinese scientists have performed a study on homozygous twins to determine how lifestyle factors - smoking, drinking, physical activity, and diet - affect biological age according to two biological age clocks. Their findings were a mixed bag, but they found evidence for eating lots of fruits and vegetables [1]. DNA methylation clocks With age, our...
Elderly woman drinking alcohol
A study funded by the National Institutes of Health has found that excessive alcohol consumption increases the epigenetic age of non-Hispanic White women according to the GrimAge epigenetic clock. Why we Age: Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of cancer and...
Reset button
An article preprint published on bioRxiv shows that a single OSKM treatment in early life provides lifelong benefits in mice. Why we Age: Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of cancer and other age-related diseases. One of the proposed reasons we...