April 12, 2021
A new technique allows researchers to turn epigenetic methylation off and back on again, thus allowing the silencing and unsilencing of certain genes. A CRISPR breakthrough CRISPR/Cas9 is a well-known technology for editing the genome, but its potential for epigenetic editing had never been previously explored. With a directed CRISPR memory writer able to methylate...
March 15, 2021
In this episode of X10, we discuss the practice of caloric restriction along with its effects, which involve the TOR signaling pathway, epigenetic alterations, and DNA repair. Sources Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. (2009) Caloric restriction delays...
March 09, 2021
Scientists have devised a transcriptome-based aging clock that allows for precise measurement of biological age in C. elegans worms and shows promising results in humans as well [1]. The purpose of aging clocks One of the central questions of longevity research is how to measure biological age. If a pathology, genetic difference, lifestyle choice, or...
March 08, 2021
Today, we chronicle the progress of partial cellular reprogramming and discuss how this powerful treatment may be able to reprogram cells back into a youthful state, at least partially reversing epigenetic alterations, one of the proposed reasons we age. For those of you new to the subject of epigenetic alterations you can learn more by...
February 15, 2021
In this episode of X10, Nicola explains a way to epigenetically reset cells using the OSKM Yamanaka factors, putting them back into a pluripotent stem cell state. These factors have also been experimentally shown to restore cells to youth in other ways, and it is also possible to carefully use these factors to make cells...
February 04, 2021
In this episode of X10, Nicola explains methylation in the context of language tones, showing how DNA methylation leads to DNA interpretations being slightly different between cells. He also introduces the idea of epigenetic clocks and discusses how gene expression, epigenetic alterations, and methylation are related. HELP SPREAD THE WORD Please connect with us on...
