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Tag: Epigenetic Alterations

Younger You
Dr. Kara Fitzgerald's new book provides an evidence-based approach to diet and lifestyle that aims to reduce your biological age. Beginning with epigenetics Younger You offers a pragmatic and easily understood primer on the role of epigenetics and aging along with an exquisitely detailed plan for how to reduce your biological age. This book is...
DNA Damage
Published in Cell, a new paper by David Sinclair and his team argues that epigenetic dysregulation in the form of information loss is a major driver of aging, but it can be reversed in vivo by partial cellular reprogramming. Genome or epigenome? Both genomic instability and epigenetic alterations are included in the Hallmarks of Aging...
RNA strand
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1]. Global changes It is well known that aging is accompanied by changes in the expression of many genes. Therefore, numerous studies have focused on identifying...
Playing mice 800x450
  Scientists have shown that continuous low-dose induction of reprogramming factors and a single early life reprogramming treatment both significantly increase lifespan and healthspan in progeroid mice while altering their epigenetic landscape [1]. In vivo reprogramming Cellular reprogramming is the process of treating cells with compounds that nudge them towards a pluripotent state. The classical...
Future Clock
In an important step for the longevity field, scientists have found that epigenetic age acceleration, as measured by four popular methylation clocks, is correlated with aging and mortality in humans [1]. Lack of human data Studying aging obviously requires having reliable biomarkers of aging. Epigenetic clocks that utilize the correlation between aging and genome methylation...
Old woman in sunlight
Using a Berlin cohort, a study published in GeroScience has uncovered a link between Vitamin D supplementation and a reduction of epigenetic age. On the back of previous work This study's cohort consisted of 60- to 85-year-old participants in the Berlin Aging Study II (BASE-II). The researchers had previously used data from this cohort to...