Tag: Epigenetic alterations

A new study has demonstrated that increasing the expression of a single gene was enough to reverse age-related visual decline in the eyes of old mice. Introducing ELOVL2 Elongation of Very Long Chain Fatty Acids Protein 2 (ELOVL2) is both a bit of a tongue twister and a known aging biomarker. The results of a...

Recently, Dr. David Sinclair did an AMA ("Ask Me Anything") on Reddit. Events like these, which allow people to ask researchers questions about their work on an open forum, can often turn up interesting responses that are not always uncovered during interviews. We have picked these few questions and answers, but we suggest that you...

This time on LE 101, Veera discusses another primary hallmark of aging, epigenetic alterations, which affect the switches that turn genes on and off - and may be surprisingly easy to reverse.

DNA damage, which results in genomic instability, is one of the primary hallmarks of aging. Today, we want to highlight an recent open access review that explores the DNA damage response during aging. The role of DNA damage Some researchers have long suggested that damage to our DNA is a major reason why we age...

A team of researchers, including Drs. Vadim Gladyshev and Steve Horvath, recently published a review of DNA methylation aging clocks, which use biomarkers to determine the biological age of a person. Aging causes epigenetic alterations to occur, including changes to DNA methylation, histone modification, transcriptional alterations (variance in gene expression), and remodeling of chromatin (a...

A recent open-access study published in Cell Stem Cell has shown that excluding Oct4 from the OSKM cocktail reduces epigenetic aberrations and off-target gene activation. Induced pluripotency and Yamanaka factors Pluripotent stem cells are cells that can become other cell types in the body; during natural development, they create differentiated stem cells and ultimately somatic...