Tag: Epigenetic Alterations

In Nature Communications, researchers have explained how epigenetic drift and disorder are associated with shorter lifespans across species. When randomness is a problem We have previously reported on research demonstrating that epigenetic clocks are most likely to be measuring noise. This paper builds on that concept, citing previous research showing that this gradual epigenetic drift...

Researchers publishing in Nature Aging have investigated one of the core biological reasons behind the decline of stem cells' ability to proliferate. Heterochromatin and euchromatin The genetic component of cells is comprised of two main parts: heterochromatin and euchromatin. Heterochromatin is largely silent, as it is a tightly packed mass that consists primarily of non-coding...

For the first time, scientists have shown that letting young and old mice share blood leads to a significant lifespan extension in the old mouse [1]. Rejuvenation by young blood Since the dawn of civilization, young blood has been credited with healing and rejuvenating powers, and its value has been demonstrated by modern science. In...

In a recent paper published in Nucleic Acids Research, researchers analyzed the organs of several mammalian species, exploring gene expression patterns associated with maximum lifespan and finding surprising correlations [1]. How and why gene expression changes As organisms age, their gene activity patterns change. To understand why, some researchers look into cross-species analysis to find...

A group of researchers led by Morgan Levine of Altos Labs has created a set of methylation clocks that can detect various aging patterns [1]. The less-than-perfect revolution The discovery that genome methylation patterns correlate with various processes of aging led to the development of methylation (epigenetic) clocks. They first appeared more than a decade...

In a new study published in Aging Cell [1], researchers report that transient activation of the Yamanaka factor Oct4 allowed partial reprogramming of cells, which led to rejuvenation in these cells and in a mouse model of premature aging. Yamanaka Factors and Partial Cellular ReprogrammingDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4,...