Tag: Epigenetic Alterations

On this episode of LifeXtenShow, Sedeer explains histones in the context of epigenetic alterations, one of the hallmarks of aging, using a library of books as an analogy. As we age, our histones change how accessible our DNA is, altering how our cells read our genome and make proteins. Some of these proteins are also...

Researchers from the Reik lab at the Babraham Institute have used the four Yamanaka reprogramming factors (OSKM) in order to epigenetically rejuvenate cells by 30 years, according to one epigenetic clock. Epigenetic AlterationsEpigenetic alterations are age-related changes in gene expression that harm the fundamental functions of cells and increase the risk of cancer and other...

LifeXtenShow has returned! In this first episode of the new year, Sedeer explains how chromatin is bundled up in the nucleus and how aging turns this bundle into a tangle, leading to genomic instability, epigenetic alterations, and age-related diseases.

In this presentation given at Ending Age-Related Diseases 2020, Tom Weldon of Ponce de Leon Health discusses ways in which epigenetic age might be reversed. His company intends to substantially increase human healthspan by using compounds that are generally recognized as safe (GRAS) as a polytherapy, hitting enough aging pathways in order to have a...

These days, it seems like you cannot go for a walk without tripping over another aging clock, and today is no exception. DeepMAge, a DNA methylation aging clock developed using deep learning, has recently been created by the Hong Kong-based company Deep Longevity. There are two common ways to measure age: biological and chronological. The...

At Ending Age-Related Diseases 2020, Dr. Eric Leire of Genflow Biosciences discussed his company, explaining what Genflow does and how it is funded. The company is intervening directly in the biology of aging, affecting SIRT6, which, like other sirtuins, is a known regulator of aging. The company intends to develop its SIRT6 plasmid as an...