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Tag: DNA

Damaged DNA
A paper published in Experimental Gerontology has provided a fresh and detailed look at the effects of oxidative stress on longevity. Revisiting an old theory The free radical theory of aging, which purports that reactive oxygen species (ROS) are the core driver of aging, was developed all the way back in 1956 [1] and expanded...
DNA Damage
Published in Cell, a new paper by David Sinclair and his team argues that epigenetic dysregulation in the form of information loss is a major driver of aging, but it can be reversed in vivo by partial cellular reprogramming. Genome or epigenome? Both genomic instability and epigenetic alterations are included in the Hallmarks of Aging...
Egg cell
A group of researchers has documented in Aging that Epitalon, a synthetic peptide made of four amino acids, slows the aging of egg cells (oocytes) after ovulation. Aging makes fertilization difficult Oocyte aging is well-known to lead to fertilization deficiencies and a host of other problems that are visible in the cells themselves, including abnormalities...
Skin aging
A group of researchers successfully alleviated aspects of skin aging by treating skin cells with the NAD precursor nicotinamide [1]. Hard work done by skin leads to its burnout Skin aging might not be lethal, apart from the increased risk of skin cancer, but it's surely conspicuous, frustrating, and emblematic of organismal aging. Being our...
Broken DNA
A review published in Frontiers in Cell and Developmental Biology has explained how DNA damage and its accompanying immune response lead to changes in the microenvironment of stem cells, causing a decline in their function. Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly...
Chromosome
A new study in Nature Genetics has further illuminated the genetic regulation of telomere length and what implications it may have for various diseases and longevity. Telomeres and aging in humans Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet...