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Tag: DNA

January 06, 2021
Research further illuminating the mechanisms of impaired DNA damage repair associated with aging has recently been published in the journal Aging. Genomic InstabilityGenomic instability is the result of gradual damage to DNA in ways that are not naturally repaired. This is a root cause of aging, and it leads to genetic mutations and an increased...
October 19, 2020
Researchers have successfully used the CRISPR/Cas9 gene editing tool to destroy Ewing's sarcoma and chronic myeloid leukemia tumor cells by targeting the fusion genes responsible for these tumors [1]. Fusion genes, a feature in many different types of cancer, arise when a mutation fuses two genes together, which typically happens when the DNA sequence between...
July 07, 2020
A group of scientists from Colorado State University has discovered that repetitive elements (REs) in our DNA increase with aging and react to known longevity-promoting interventions [1]. Are REs genomic parasites? At the dawn of genomic research scientists were stunned to learn that as much as 95% of our genome is non-coding: it does not...
March 29, 2020
This month the Journal Club returns with a double helping of science! Dr. Oliver Medvedik will be hosting the Journal Club this month and covering not one, but two scientific publications. The first is the 2014 "A three-dimensional map of the human genome at kilobase resolution reveals principles of chromatin looping" paper [1]. We use...
February 12, 2020
DNA origami, a nano-scale technique used to make very tiny smiley faces out of DNA, is becoming increasingly valuable for drug delivery and other applications, paving the way for true nanomedicine. What is DNA origami? Ever since Richard Feynman famously proclaimed in his seminal 1959 talk that "there’s plenty of room at the bottom", nanotechnology...
January 10, 2020
A new open-access review published in Trends in Cell Biology sheds light on both the causes and consequences of genomic instability, the DNA damage that is one of the primary hallmarks of aging. Sources of Damage A substantial portion of genomic instability is caused by unwanted reactions with chemicals that we need to survive. Oxidation...