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Tag: DNA

Chromosome
A new study in Nature Genetics has further illuminated the genetic regulation of telomere length and what implications it may have for various diseases and longevity. Telomeres and aging in humans Why we age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet...
Breast cancer
Cells from the breasts of women with mutations that increase their risk of breast cancer shows signs of accelerated aging, according to new research [1]. Accelerated aging may make these cells worse at suppressing cancer development, offering both an explanation for the effect of these mutations and an unexplored path for possible treatments. Risky mutations...
Rendering of chromosomes
In a preprint paper, scientists have announced the completion of the first full, telomere-to-telomere, sequencing of the human genome, more than two decades after the first draft of its sequencing. This was made possible by new sequencing technologies [1]. Mind the gaps The human genome was first reported as being sequenced two decades ago by...
Magnifying glass on DNA
Senescent cells are surprisingly hard to identify, but a recent publication in Tissue and Cell makes the case for using cytoplasmic DNA as a marker of senescence. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...
Centenarian
A new study has shown that people who live for over 105 years typically have a genetic makeup that allows better repair of DNA damage [1]. Looking at the genomes of people who enjoy extreme longevity There has always been lots of interest in what allows some people to live considerably longer than their peers,...
double strand break
Research further illuminating the mechanisms of impaired DNA damage repair associated with aging has recently been published in the journal Aging. Why we age: Genomic InstabilityGenomic instability is the result of gradual damage to DNA in ways that are not naturally repaired. This is a root cause of aging, and it leads to genetic mutations...