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Tag: Diabetes

Metformin
An outcomes study conducted by the Diabetes Prevention Program (DPP) has examined the effects of lifestyle interventions and the popular diabetes drug metformin on all-cause mortality. Background The original DPP was conducted at 27 centers in the United States from 1996 to 2001. Building upon this work, the Centers for Disease Control developed a national...
Thoughtful old man
A team of Spanish researchers has examined how glucose imbalance leads to neurological disorders through the failure of adipocytokines. What are adipocytokines? These compounds' name seems a bit concerning: "adipo-" refers to fat, and a cytokine is a cellular signal most commonly known for being part of the deadly cytokine storm associated with severe immunological...
Alpha-lipoic acid (also known as ALA) is a common supplement, and we take a look at it in the context of aging. What is alpha-lipoic acid? Alpha-lipoic acid is an organosulfur (an organic compound that contains sulfur) derived from caprylic acid (also known as octanoic acid). It was first discovered in 1937, when Snell found...
Muscle fibers
In recent years, there has been considerable interest in the naturally occurring molecule and dietary supplement nicotinamide mononucleotide (NMN) and its potential influence on aging. While there have been numerous animal studies suggesting that it may be useful in combating some age-related decline, there has been a lack of human data until now. In previous...
Welcome to part two of a two-part series exploring NAD+ biology; you can find part one here. There are already a myriad of excellent reviews on NAD+ biology in general [1-3], so, in this article, we will be mainly focusing on the NAD+ precursor nicotinamide mononucleotide (NMN). NMN and synthesis of NAD+ NMN can be...
A recent study published in Cell Metabolism has shown that metformin, a drug that has been previously shown to be effective against some aspects of aging, ameliorates inflammaging by promoting autophagy, the cellular recycling of damaged components. Mitochondrial dysfunction, autophagy, and TH17 Mitochondrial dysfunction is one of the hallmarks of aging, the root causes that...