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Tag: Crosslinks

October 12, 2020
On Wednesday, October 28th at 1:00 PM EDT, Dr. Oliver Medvedik returns with the Journal Club live on our Facebook page; the topic this month is glucosepane breakers and a recent paper that takes a step forwards in making them a reality. The new research takes us a step close to finding ways to remove...
July 15, 2020
Two researchers, Alexander Fedintsev and Alexey Moskalev, have published an expansive review paper in which they propose a new hallmark of aging [1]. The authors draw our attention to a phenomenon that is sometimes overlooked in the context of aging: the accumulation of damage to long-lived molecules caused by the non-enzymatic chemical reactions of glycation,...
January 08, 2020
Some pleasant news has recently arrived: Revel Pharmaceuticals has successfully completed a seed round in order to begin developing therapeutics that target glucosepane crosslinks, which are a proposed reason why we age, develop diseases such as diabetes, and suffer from stiffened arteries and hypertension. In the business of startups, a seed round refers to a...
June 03, 2019
For the May Journal Club, Dr. Medvedik and guests took a look at the recent publication by the Spiegel Lab at Yale University where two forms of advanced glycation end products (AGEs) were successfully cleaved. We also covered this important breakthrough in our article – Reversal of Two Advanced Glycation End Products Achieved. Abstract Advanced glycation end products...
November 20, 2018
At the Eurosymposium on Healthy Ageing, we had the opportunity to interview Sven Bulterijs of the Healthy Life Extension Society (HEALES). Some of our regular readers may recall seeing Sven join us for some of the monthly episodes of the Journal Club and he is an active figure in the rejuvenation biotechnology field.  During the...
April 19, 2018
Some time ago, we discussed the matter of beauty in the context of life extension; in particular, we tried to dispel the belief that the motivation behind life extension might be simply vanity. The article argued that there is nothing wrong with wanting to preserve youthful looks and attempted to explain the evolutionary reasons for...