Tag: CRISPR

Researchers publishing in Cell Reports Medicine have taken a look at what causes CRISPR/Cas9 gene-editing technology to drive cells senescent and investigated a potential method of preventing it. Breaking and repairing DNA Genetic engineering of living cells through CRISPR/Cas9 technology requires three things to occur. The DNA must be disconnected in a double-strand break, new...

Researchers publishing in Cell Stem Cell have demonstrated that genetically diseased liver cells can be taken from human beings, altered in the laboratory, and used to regrow the livers of model mice. Recreating an entire organ has its own difficulties These researchers begin their paper by discussing existing cellular therapies for multiple tissues, such as...

Researchers publishing in Cell Stem Cell have announced a new method of accurately and rapidly cloning genetically engineered stem cells. CRISPR is still imperfect While the accuracy of genetic modification through the well-known CRISPR/Cas9 system continues to improve, the technology remains imperfect. Small mistakes were initially reported [1], and later researchers found that under certain...

A team of researchers from multiple Japanese universities has found a way to genetically enhance T cells against solid tumors, as published today in Nature Biomedical Engineering. A focus on signals This highly in-depth paper begins with a discussion of signaling in the response of chimeric antigen receptor (CAR) T cells, as good signals are...

Publishing in Nature, scientists from the University of Texas report the discovery of a small molecule that can stop an especially aggressive subtype of breast cancer [1]. The deadliest kind Breast cancer remains the fourth deadliest type of cancer, claiming more than 40 thousand victims a year, almost exclusively women, in the US alone. Like...

Scientists have proposed a novel method of cellular reprogramming that is more predictable and effective than traditional methods [1]. Geroscience's Holy Grail Cellular reprogramming is a hot topic in geroscience that is being pursued by many academics and companies, including major players such as Google's Calico along with Altos Labs, which is backed by Jeff...