Tag: CRISPR

The Journal Club hosted by Dr. Oliver Medvedik will return live to our Facebook Page at 12:00 EST on Tuesday 27th of April. This month we will be taking a look at a new paper and technique for the gene editing tool CRISPRcas9. The technique allows researchers to turn epigenetic methylation off and back on...

A new technique allows researchers to turn epigenetic methylation off and back on again, thus allowing the silencing and unsilencing of certain genes. A CRISPR breakthrough CRISPR/Cas9 is a well-known technology for editing the genome, but its potential for epigenetic editing had never been previously explored. With a directed CRISPR memory writer able to methylate...

Scientists have successfully tested a new nanoparticle-based delivery system for CRISPR kits, achieving drastic improvements in mouse models of glioblastoma and ovarian cancer [1]. A gift from our single-cell ancestors CRISPR gene editing technology has been widely hailed as a potential game changer in medicine, including anti-cancer therapy. CRISPR’s ability to permanently disrupt tumor survival...

Researchers have successfully used the CRISPR/Cas9 gene editing tool to destroy Ewing's sarcoma and chronic myeloid leukemia tumor cells by targeting the fusion genes responsible for these tumors [1]. Fusion genes, a feature in many different types of cancer, arise when a mutation fuses two genes together, which typically happens when the DNA sequence between...

A group of researchers has used CRISPR to create energy-dissipating brown adipocytes (fat cells) from white preadipocytes. The new cells were then shown to alleviate obesity in mice [1]. Obesity: the nemesis of longevity Obesity is one of humanity’s deadliest enemies. It is a known comorbidity in a plethora of diseases, including age-related, such as...

Researchers have developed what can be described as the first precision gene editing tool for mitochondrial DNA (mtDNA). This new tool is different from the well-known CRISPR/Cas9 method of gene editing and should make the study of mitochondrial biology and mitochondrial diseases easier. This new discovery is a game changer Prior to this, creating mouse...