Tag: CRISPR

Publishing in Nature, scientists from the University of Texas report the discovery of a small molecule that can stop an especially aggressive subtype of breast cancer [1]. The deadliest kind Breast cancer remains the fourth deadliest type of cancer, claiming more than 40 thousand victims a year, almost exclusively women, in the US alone. Like...

Scientists have proposed a novel method of cellular reprogramming that is more predictable and effective than traditional methods [1]. Geroscience's Holy Grail Cellular reprogramming is a hot topic in geroscience that is being pursued by many academics and companies, including major players such as Google's Calico along with Altos Labs, which is backed by Jeff...

Scientists have managed to extend the lifespan of C. elegans nematode worms by as much as 135% by blocking an insulin-related pathway very late in life [1]. The long-lived mutants Back in the late 80s and early 90s, experiments with C. elegans, tiny nematode worms, became one of geroscience's first major successes. Scientists showed that...

Publishing in Science Advances, a team of researchers has described how a scaffold containing genetically engineered induced pluripotent stem cells (iPSCs) can reduce symptoms in a mouse model of rheumatoid arthritis. The advantage over current drugs Rheumatoid arthritis (RA) is currently treated through drugs that often suppress the immune system as a side effect [1]....

In a study published in Genome Biology, researchers explain how they are working to make CRISPR less prone to large, accidental deletions of genetic material [1]. A previously unknown large problem While this seems counterintuitive, previous technology only allowed for the ready identification of deletions below 100 base pairs. New technology has allowed for larger...

Professor of Genetics at Harvard Medical School and one of the most prominent geroscientists, George Church works on gene therapies that can potentially reverse age-related diseases. We had the opportunity to interview this prolific researcher and entrepreneur, who is involved in dozens of startups, on topics ranging from the current state of gene therapy to...