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Tag: CD38

Two running mice
Scientists from Mayo Clinic have significantly extended lifespan in male mice by inhibiting the enzyme CD38, which lowers NAD levels [1]. The age-related decline of nicotinamide dinucleotide (NAD) has been associated with various metabolic abnormalities, age-related diseases, and fitness loss. What is Nicotinamide Adenine Dinucleotide?Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living...
Chamomile is a great source of Apigenin.
This active ingredient in chamomile tea has traditionally been used to ease anxiety and reduce stress. We investigate if the scientific studies support this traditional use and how it relates to aging. What is apigenin? Apigenin is a very common and widely distributed flavonoid in the plant kingdom. Flavonoids are a class of naturally occurring...
Complicated machinery
Aging is a multifactorial and complex process; indeed, it is probably the most complex disorder known. It is made up of a combination of dozens of malfunctions locked together in an accelerating spiral of decline. Despite this undeniable complexity, which is captured to some extent by grouping the many age-related dysfunctions into nine categories often...
CD38 protein image
We recently explored why NAD+ declines during aging, and today, we want to spotlight a new review that takes a deep dive into CD38, one of the reasons for this decline [1]. What is Nicotinamide Adenine Dinucleotide?Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a dinucleotide, which means that...
Inflamed knee
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells and is essential for cells to work; without it, life would be impossible. The connection between aging and the accompanying loss of NAD+ has been the subject of much research, and a new study sheds light on why this happens. What is Nicotinamide...
Diagram of NADH
There has been considerable debate around the age-related decline of NAD+, particularly regarding whether or not it occurs in humans as it does in other species, such as mice. Today, as part of a two-part special, we are going to be taking a look at some of the evidence for the age-related decline of NAD+...

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