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Tag: CD38

Complicated machinery
February 12, 2021
Aging is a multifactorial and complex process; indeed, it is probably the most complex disorder known. It is made up of a combination of dozens of malfunctions locked together in an accelerating spiral of decline. Despite this undeniable complexity, which is captured to some extent by grouping the many age-related dysfunctions into nine categories often...
CD38 protein image
December 08, 2020
We recently explored why NAD+ declines during aging, and today, we want to spotlight a new review that takes a deep dive into CD38, one of the reasons for this decline [1]. Nicotinamide Adenine DinucleotideNicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a dinucleotide, which means that it consists...
Inflamed knee
November 18, 2020
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells and is essential for cells to work; without it, life would be impossible. The connection between aging and the accompanying loss of NAD+ has been the subject of much research, and a new study sheds light on why this happens. Nicotinamide Adenine DinucleotideNicotinamide...
July 23, 2020
There has been considerable debate around the age-related decline of NAD+, particularly regarding whether or not it occurs in humans as it does in other species, such as mice. Today, as part of a two-part special, we are going to be taking a look at some of the evidence for the age-related decline of NAD+...
Macrophage engulfing bacteria
April 15, 2020
Researchers have found that a protein called TIM-4 is essential to macrophages' ability to clean up cellular debris and that p38 MAPK, a protein that increases due to aging, inhibits TIM-4. Inflammaging and immunosenescence Aging is the primary risk factor for a myriad of chronic age-related diseases, including heart disease, Parkinson's, Alzheimer's, and cancer. As...
Mouse looking at the camera
February 17, 2020
Mitochondria provide our cells with the energy they need to function, and they become increasingly dysfunctional as we age. A new study suggests that mitochondrial rejuvenation in the context of restoring healthy blood flow and neurovascular health might be possible with the popular supplement NMN. Rejuvenation of aged mitochondria The mitochondria are the power stations...