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Tag: CD38

November 18, 2020
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells and is essential for cells to work; without it, life would be impossible. The connection between aging and the accompanying loss of NAD+ has been the subject of much research, and a new study sheds light on why this happens. Nicotinamide Adenine DinucleotideNicotinamide...
July 23, 2020
There has been considerable debate around the age-related decline of NAD+, particularly regarding whether or not it occurs in humans as it does in other species, such as mice. Today, as part of a two-part special, we are going to be taking a look at some of the evidence for the age-related decline of NAD+...
April 15, 2020
Researchers have found that a protein called TIM-4 is essential to macrophages' ability to clean up cellular debris and that p38 MAPK, a protein that increases due to aging, inhibits TIM-4. Inflammaging and immunosenescence Aging is the primary risk factor for a myriad of chronic age-related diseases, including heart disease, Parkinson's, Alzheimer's, and cancer. As...
February 17, 2020
Mitochondria provide our cells with the energy they need to function, and they become increasingly dysfunctional as we age. A new study suggests that mitochondrial rejuvenation in the context of restoring healthy blood flow and neurovascular health might be possible with the popular supplement NMN. Rejuvenation of aged mitochondria The mitochondria are the power stations...
June 11, 2019
A new publication highlights how the complex interaction of NAD+ and cellular senescence pathways may complicate proposed anti-aging therapies that boost NAD+ using precursors. What are epigenetic alterations? One of the proposed reasons we age is the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations....
November 09, 2018
Today, we want to highlight a recent, small-scale study looking at NAD+ and how it declines with age in the plasma. The researchers looked at various NAD+ metabolites across age groups and found that the amounts of some of them, particularly NAD+ itself, are significantly smaller in older people than younger ones [1]. This is...