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Tag: Atherosclerosis

Clogged pipes
In a new study published in Oxidative Medicine and Cellular Longevity, the researchers have shown that klotho ameliorates vascular calcification via increased autophagy [1]. ‘Rusty’ arteries Vascular calcification, the deposition of minerals in the cardiovascular system, is a complex pathological process that accompanies aging. It is associated with an increased risk of stroke, coronary artery...
Atherosclerosis
Scientists have drastically improved various symptoms of atherosclerosis in mice by precisely targeting mitochondria with a plant-derived antioxidant [1]. Age-related and deadly Atherosclerosis, the accumulation of plaques on arterial walls, is one of the deadliest age-related diseases. Atherosclerotic plaques, which consist mostly of cholesterol and fat, can impede blood flow in the artery or burst,...
Cholesterol
Underdog Pharmaceuticals has just issued a press release announcing that UDP-003, a compound being studied for its effectiveness against oxidized cholesterol, has been given an Innovation Passport under the UK's Innovative Licensing and Access Pathway program. This is similar to the Fast Track designation given by the FDA in the United States. Underdog is a...
Blood cells in an artery
Today, we want to highlight the results of a recent long-term study, which collected data over a four-year period to investigate the link between aortic stiffening and cognitive decline, including dementia. During aging, our blood vessels become increasingly stiff and lose their flexibility, and the cells comprising it struggle to contract and relax properly. Blood...
DNA mutation
A new perspective published in Cell explains a direct link between genomic instability and age-related diseases [1]. Somatic mutations Mutation is normally explained as the driving force behind evolution, as changes in the germ lines of organisms result in beneficial and harmful mutations to organisms. The organisms with the harmful mutations die off and the...
Red meat
Researchers suggest that trimethylamine, a metabolic byproduct that is created when bacteria in the gut break down foods such as red meat, may be a key player in vascular aging. Trimethylamine and vascular aging Some researchers believe that trimethylamine damages our arteries, according to a new study conducted by researchers at the University of Colorado...

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