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Tag: αKlotho

Mice and food
New senolytics data was released from Dr. James L. Kirkland’s Mayo Clinic lab and published in The Lancet [1]. Prior studies have shown that α-Klotho protein decreases with age in mice and humans [2,3]. It has also been demonstrated that mice that lack α-Klotho have shorter lifespans, cognitive impairment, sarcopenia, vascular dysfunction, osteopenia, cardiac hypertrophy...
Three Fates
A recent study in The Journals of Gerontology, Series A has associated low klotho levels with mortality in Americans over the age of 40. Klotho and aging What is Klotho?Klotho, named after the Greek mythological figure, is an enzyme that can be either circulating or bound to cell membranes. It is expressed most highly in...
Arthritic joint pain
Researchers have successfully reversed the course of osteoarthritis in rats by combining two molecules, one of which, a-Klotho, has long been a popular subject of anti-aging research. A classic age-related disease Osteoarthritis (OA) is a classic example of a wear-and-tear disease. Its manifestations are in the slow degeneration of articular cartilage, the appearance of bone...