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Amutha Boominathan on the MitoMouse at EARD2019

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We’re releasing yet another talk from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology.

This talk is from Amutha Boominathan of SENS Research Foundation, who discussed her work with mitochondria – some of which was unpublished at the time, which is why this talk had not been released until now. Beginning by explaining the roots of mitochondrial dysfunction and its effects, she went on to describe the differences between codons in the mitochondria and the nucleus, the concept of codon optimization, and the challenges and practices of migrating mitochondrial DNA to the nucleus, which is the goal of the MitoSENS project. Finally, she discussed the MitoMouse project, a mouse model that shows that mitochondrial proteins can be effectively expressed with nuclear DNA, a technique that may be used in the future as a therapy for mitochondrial dysfunction.





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