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Month: February 2023

Matthew O'Connor Interview
Cyclarity Therapeutics is striving to make powerful treatments for cardiovascular disease and, most importantly, make them accessible and affordable. Their cutting-edge cyclodextrin technology targets atherosclerosis, aiming to eliminate the buildup of non-degradable oxidized cholesterol that gets stuck inside cells in the arterial walls. The company has made great progress towards launching its cyclodextrin drug for...
NOVOS logo
With multiple experts on its scientific advisory board, NOVOS offers supplements containing ingredients that recent research has linked to longevity. This company also markets biological age tests for people who want to monitor their progress. We spoke with NOVOS founder and CEO Chris Mirabile about the company’s ideology and approach. Please explain the science behind...
LSN NAD Heart Failure
On this episode of Lifespan News, Emmett Short discusses how a compound known as Kdm8 is critical in getting NAD+ to heart muscles and preventing a form of heart disease. Script Until we all have ARC reactor hearts that can be replaced by anyone with small enough hands to reach inside the socket. Heart transplants...
Advanced clock
A team publishing in Human Genomics has developed a new model for analyzing epigenetic changes that uses nonlinear analysis. Current clocks are linear Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many different...
Brain tumor
Combining results from human tumors and a mouse model, researchers publishing in Nature Communications have shown that senescent cells promote the growth of glioblastoma, a form of brain cancer. Deadly, aggressive, and hard to treat Glioblastoma is one of the most dangerous forms of cancer. Even surgery, radiotherapy, and chemotherapy do little against this invasive...
Genetic erasure
In a new study published in Nature Aging, scientists have shown that targeted ablation of neuronal APOE4, which produces the ApoE4 protein, significantly protects against Alzheimer’s disease in a mouse model [1]. The dreadful allele An infamous variant of the APOE gene, APOE4, is the strongest risk factor for late-onset Alzheimer’s disease [2]. People heterozygous...