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Month: February 2022

Brain Image
Cardiologists, epidemiologists, and other researchers publishing in Aging have discovered that epigenetic aging and brain scans can be combined to accurately predict cognitive decline. Two entirely different measurements The ongoing CARDIA study was started in 1985 to monitor coronary artery risk development in young adults (who are no longer young). This large cohort has been...
Rat Look
Scientists have shown that resveratrol rescues erectile function in aged rats, most probably by activating SIRT1, and that it can work in synergy with the existing erectile dysfunction treatment tadalafil [1]. A molecule of discord Resveratrol, a plant-derived chemical of the polyphenol family, was once considered one of the most promising anti-aging molecules. David Sinclair’s...
Running Mice
A team of researchers, including Steve Horvath, Leonid Peshkin, and Vadim Gladyshev, has published a preprint on bioRxiv showing the effects of early administration of rapamycin over the lifespans of mice. Rapamycin before and after weaning In this placebo-controlled experiment, the researchers selected the UMHET3 strain of mice, as it is a crossbreed that does...
Skeletal Muscle
A study published in the Journal of the American Medical Association has examined the dosage and safety of a urolithin A supplement [1]. This study also examined urolithin A's effect on muscle endurance and specific health biomarkers. A randomized, controlled clinical trial  This study is a follow-up to prior work done by the Amazentis company,...
Exercising man
In a study published in Nature Aging, a group of scientists has shown that NAD+ levels are correlated not only with age but with physical activity, with elder athletes rivaling normal young adults [1]. NAD: small, crucial, age-related Nicotinamide adenine dinucleotide (NAD) is as important as it is tiny. As its name suggests, this molecule...
Pankaj Kapahi Interview
Dr. Pankaj Kapahi is a veteran geroscientist. His laboratory at the famous Buck Institute for Research on Aging is among the few that study advanced glycation end products (AGEs) and the many ways in which they affect aging. Dr. Kapahi's company, Juvify, produces GLYLO, a supplement for detoxifying AGEs that also reduces food cravings. In...

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