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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/https://www.fightaging.org/newsletter/Longevity Industry Consulting ServicesReason, the founder...

There is no situation so terrible that it will not be silently accepted as set in stone, only given that it has lasted for long enough to become routine. So it is with aging, and all of the pain, suffering, and death that accompanies it. The present furor surrounding COVID-19 is unusual for casting at...

The present consensus on how particulate air pollution (such as wood smoke from cooking fires, still commonplace in much of the world) causes an acceleration of age-related disease and mortality is that this is a matter of inflammation. Particules lodge in the lungs, and there spur chronic inflammation that drives onset and progression of all...

The common neurodegenerative conditions are associated with various different forms of protein aggregation; a few proteins in the body have toxic alternative forms that can spread and cause harm to cells. Alzheimer's disease is associated with amyloid-β and tau, Parkinson's disease with α-synuclein, and so forth. But the decay of the aging brain is not...

Cell and tissue biology always turns out to be more complicated than we would all prefer. Present understanding is rarely complete to the point at which all obstacles are known. It is one of the reasons why the development of new classes of medical therapy is a challenging business. Consider the topic of autophagy in...

Excess visceral fat tissue generates chronic inflammation via a range of mechanisms, including an accelerated creation of senescent cells. Most of the commmon age-related conditions have an inflammatory component, and thus people who are overweight or obese suffer a raised risk of age-related disease, higher lifetime medical costs, and a shorter life expectancy. This is...