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All times are in Eastern Daylight Time (EDT).
Day 1, Thursday, August 20th
| 9:00 – 9:10 Welcome talk by LEAF President Keith Comito |
| 9:10 – 9:20 Welcome talk by LEAF Vice President Oliver Medvedik, Director of the Maurice Kanbar Center for Biomedical Engineering |
| 9:20 – 10:00 Opening keynote |
| Aubrey de Grey – SENS Research Foundation Maximizing the pace of biomedical gerontology in a pandemic-conscious world 10:00 – 10:05 Q&A |
| 10:05 – 10:15 LIFESPAN Documentaries Premiere by Tim Maupin |
| 10:15 – 11:45 Session 1: Biomarkers of aging |
| Steve Horvath – UCLA Epigenetic Clocks for Clinical and Preclinical Applications |
| Polina Mamoshina – Insilico Medicine Deep Biomarkers of Human Aging |
| Lorna Harries – University of Exeter Alternative RNA processing: a new senotherapeutic target? |
| Premium Event 11:45 – 12:30 Panel Discussion: Biomarkers of aging: Significance for R&D and therapeutic application Chair: Vadim Gladyshev Participants: Steve Horvath (UCLA), Kristen Fortney (BioAge Labs), Stanislav Skakun (BioData), Peter Fedichev (GERO) |
| 11:45 – 12:30 Dr. Ronald Kohanski (NIA) and Keith Comito (Lifespan.io) The NIA’s Systemic Approach to Extending Healthy Lifespan |
| 12:15 – 12:30 Sponsor presentations |
| Alexander Fedintsev – Institute of Biology of the Komi Science Centre of the Ural Division of RAS Collagen glycation: beyond vascular stiffness and hypertension |
| Gabriela Bunu – Institute of Biochemistry of the Romanian Academy SynergyAge: a curated database for synergistic and antagonistic interactions of longevity- associated genes |
| 12:30 – 2:00 Session 2: Fundamental studies of the root mechanisms of aging, part 1 |
| Judith Campisi – The Buck Institute for Research on Aging Targeting senescent cells to alleviate aging: A simple task? |
| Alexey Moskalev – Institute of Biology of the Komi Science Centre of the Ural Division of RAS Genetic mechanisms of aging and longevity on the Drosophila model |
| Jonathan Clark – Babraham Institute A new perspective on the changes in tendon collagen crosslinking with age and the impact on function |
| Premium Event 2:00 – 2:45 Panel discussion: Public perception of research on aging Chair: Elena Milova (Lifespan.io) Panelists: Daria Khaltourina (International Longevity Alliance), Roey Tzezana (XPRIZE), Maria Entraigues Abramson (SENS Research Foundation) |
| 2:00 – 2:30 Poster Session Two 15-minute presentations by young researchers |
| Alexander Fedintsev – Institute of Biology of the Komi Science Centre of the Ural Division of RAS Collagen glycation: beyond vascular stiffness and hypertension |
| Gabriela Bunu – Institute of Biochemistry of the Romanian Academy SynergyAge: a curated database for synergistic and antagonistic interactions of longevity- associated genes |
| 2:30 – 3:00 Dr. Daria Khaltourina (ILA) and Elena Milova (Lifespan.io) Does Aging Meet the WHO Criteria for Classification as a Disease? |
| 3:00 – 4:30 Session 3: Fundamental studies of the root mechanisms of aging, part 2 |
| Irina Conboy – UC Berkeley Preventing, attenuating and reversing diseases of old age as a class: young blood is not required |
| Vadim Gladyshev – Harvard Medical School Quantifying and manipulating the aging process |
| Andrei Gudkov – Roswell Park Comprehensive Cancer Center Endogenous Retrobiome and Immunosenescence as Targets for Antiaging Therapies |
| 4:30 – 5:10 Interview with David Wood (London Futurists) Humanity and Longevity: Past, Present and Future |
| 5:10 – 5:55 Panel Discussion: Acceleration of human rejuvenation trials: The path from research to application Chair: Michael Geer (Humanity) Panelists: Aubrey de Grey (SENS Research Foundation), Gregory Fahy (Intervene Immune), Kevin Perrott (OpenCures), Sajad Zalzala (AgelessRx), Steve Horvath (UCLA) |
| 5:55 – 6:00 PM Roundup Notes by the Chair |
Day 2, Friday, August 21st
| 9:00 – 9:05 Welcome talk by LEAF VP Oliver Medvedik |
| 9:05 – 9:45 Opening keynote Brian Kennedy – National University of Singapore Preventive Medicine in an Ageing Society (Beyond Healthcare to Health) |
| 9:45 – 9:50 Q&A |
| 9:50 – 10:00 Kids and Life Extension by Tim Maupin |
| 10:00 – 11:00 Session 4: Investing in rejuvenation, part 1 |
| David Gobel – Methuselah Foundation We need to get back to the future – The Poison Squad vs the Nuremberg Code |
| Alexandra Bause – Apollo Ventures Biotech VC meets Impact Investing with the Mission to Enhance Human Health |
| Premium Event 11:00 – 11:45 LEAF Panel Discussion: Role of media in engaging early adopters Chair: Keith Comito (Lifespan.io) Panelists: Sonia Arrison (100 Plus Capital), Pat Graziosi (Life Noggin), Greg Grinberg (ActualFood, Life+), Tim Maupin (TWOCOATS Film Production, Lifespan.io) |
| 11:00 – 11:15 Interview with Michael Greve (Forever Healthy Foundation) Rejuvenation Now: Sharing Vital Knowledge with the Public |
| 11:15 – 11:45 Interview with Dr. Mair Underwood Factors That Influence Public Views on Rejuvenation |
| 11:45 – 12:45 Session 5: Investing in rejuvenation, part 2 |
| Sergey Young – Longevity Vision Fund Why Longevity Is the Next Trillion Dollar Opportunity |
| Javier Noris – Lifespan.io The Longevity Impact Fund – Funding Translational Longevity Research |
| 12:45 – 1:30 Panel Discussion: How to Overcome the Valley of Death? Chair: Javier Noris (Lifespan.io) Panelists: Patrick Burgermeister (Kizoo Ventures), Reason (Repair Biotechnologies), Sergio Ruiz (Methuselah Fund), Ronjon Nag (Institute R42) |
| 1:30 – 3:00 Session 6: Targeting aging with interventions, part 1 |
| Lewis Gruber – SIWA Therapeutics A Comprehensive Therapy for Cancer and Other Aging-Associated and Degenerative Diseases – Attacking Senescent Cells and Cancer Cells Simultaneously |
| James Kirkland – Mayo Clinic Aging, Senescent Cells, and Senolytics |
| Marco Quarta – Rubedo Life Sciences Targeted senolytic systemic treatments for geriatric syndromes |
| 3:00 – 3:40 Interview with Stanislav Skakun (BioData) The Power of Quantified Self for Creating a Longevity Strategy |
| 3:40 – 5:10 Session 7: Targeting aging with interventions, part 2 |
| Reason – Repair Biotechnologies Towards Reversal of Atherosclerosis |
| Hanadie Yousef – Juvena Therapeutics Harnessing the Regenerative Secretome of Pluripotent Stem Cells to Rejuvenate Aged Tissues |
| Matthew O’Connor – SENS Research Foundation, Underdog Engineering drugs for the removal of toxic metabolites with aging |
| 5:10 – 5:15 The Last Generation to Die (trailer) by Tim Maupin |
| 5:15 – 6:15 Session 8: Targeting aging with interventions, part 3 |
| Peter Fedichev – GERO Engineering rejuvenation therapeutics with AI |
| Joshua Mittledorf – School of Medicine, Washington University in St Louis Are Methylation Clocks a Reliable Gauge of Anti-Aging Interventions? |
| 6:15 – 6:20 PM Closing remarks by LEAF President Keith Comito |
Lifespan Factory – On-Demand Track
| Kelsey Moody – Ichor Therapeutics 2019 Workshop: Developing a Biotechnology Startup in the Rejuvenation Field |
| Isabelle Schiffer – Forever Healthy Foundation Rejuvenation therapies from bench to bedside – where are we now? |
| Thomas Weldon – Ponce de Leon Health How to reverse your epigenetic age now |
| Sajad Zalzala – AgelessRx Phase IV Rapamycin Longevity Trial: a Paradigm Shift in Human Longevity Clinical Trials |
| Ronjon Nag – R42 Group AI and Aging |
| Tyler Golato – Molecule Molecule: Decentralized Drug Development and a New Financing Pathway for Longevity Therapeutics |
| Eric Leire – GenFlow Genflow Biosciences: A Disruptive Approach to Longevity Therapies |
| Gordan Lauc – GlycanAge Using Glycans as a Tool to Prevent Age-Related Diseases |
| Paul Spiegel – Eclectic Law Beyond Retirement: A New Social Compact for the Age of Longevity |
| Kris Verburgh – NOVOS The high-tech and low-tech approach to longevity: overview and ways to identify promising longevity technologies and approaches |
| Edward Layne – AgeMeter Testing Functional Age and Screening for Covid-19 |
| Greg Grinberg – ActualFood TBA |
| Evan Snyder – National Institute of Health TBA |
| Michael Geer – Humanity.Health Collaborating to Increase the Healthspan of Humanity |
