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All times are in Eastern Daylight Time (EDT).

Day 1, Thursday, August 20th

9:00 – 9:10 Welcome talk by LEAF President Keith Comito
9:10 – 9:20 Welcome talk by LEAF Vice President Oliver Medvedik, Director of the Maurice Kanbar Center for Biomedical Engineering
9:20 – 10:00 Opening keynote
Aubrey de Grey – SENS Research Foundation
Maximizing the pace of biomedical gerontology in a pandemic-conscious world
10:00 – 10:05 Q&A
10:05 – 10:15 LIFESPAN Documentaries Premiere by Tim Maupin
10:15 – 11:45 Session 1: Biomarkers of aging
Steve Horvath – UCLA
Epigenetic Clocks for Clinical and Preclinical Applications
Polina Mamoshina – Insilico Medicine
Deep Biomarkers of Human Aging
Lorna Harries – University of Exeter
Alternative RNA processing: a new senotherapeutic target?
Premium Event
11:45 – 12:30 Panel Discussion: Biomarkers of aging: Significance for R&D and therapeutic application
Chair: Vadim Gladyshev
Participants: Steve Horvath (UCLA), Kristen Fortney (BioAge Labs), Stanislav Skakun (BioData), Peter Fedichev (GERO)
11:45 – 12:30 Dr. Ronald Kohanski (NIA) and Keith Comito (Lifespan.io)
The NIA’s Systemic Approach to Extending Healthy Lifespan
12:15 – 12:30 Sponsor presentations
Alexander Fedintsev – Institute of Biology of the Komi Science Centre of the Ural Division of RAS
Collagen glycation: beyond vascular stiffness and hypertension
Gabriela Bunu – Institute of Biochemistry of the Romanian Academy
SynergyAge: a curated database for synergistic and antagonistic interactions of longevity- associated genes
12:30 – 2:00 Session 2: Fundamental studies of the root mechanisms of aging, part 1
Judith Campisi – The Buck Institute for Research on Aging
Targeting senescent cells to alleviate aging: A simple task?
Alexey Moskalev – Institute of Biology of the Komi Science Centre of the Ural Division of RAS
Genetic mechanisms of aging and longevity on the Drosophila model
Jonathan Clark – Babraham Institute
A new perspective on the changes in tendon collagen crosslinking with age and the impact on function
Premium Event
2:00 – 2:45 Panel discussion: Public perception of research on aging
Chair: Elena Milova (Lifespan.io)
Panelists: Daria Khaltourina (International Longevity Alliance), Roey Tzezana (XPRIZE), Maria Entraigues Abramson (SENS Research Foundation)
2:00 – 2:30 Poster Session
Two 15-minute presentations by young researchers
Alexander Fedintsev – Institute of Biology of the Komi Science Centre of the Ural Division of RAS
Collagen glycation: beyond vascular stiffness and hypertension
Gabriela Bunu – Institute of Biochemistry of the Romanian Academy
SynergyAge: a curated database for synergistic and antagonistic interactions of longevity- associated genes
2:30 – 3:00 Dr. Daria Khaltourina (ILA) and Elena Milova (Lifespan.io)
Does Aging Meet the WHO Criteria for Classification as a Disease?
3:00 – 4:30 Session 3: Fundamental studies of the root mechanisms of aging, part 2
Irina Conboy – UC Berkeley
Preventing, attenuating and reversing diseases of old age as a class: young blood is not required
Vadim Gladyshev – Harvard Medical School
Quantifying and manipulating the aging process
Andrei Gudkov – Roswell Park Comprehensive Cancer Center
Endogenous Retrobiome and Immunosenescence as Targets for Antiaging Therapies
4:30 – 5:10 Interview with David Wood (London Futurists)
Humanity and Longevity: Past, Present and Future
5:10 – 5:55 Panel Discussion: Acceleration of human rejuvenation trials: The path from research to application
Chair: Michael Geer (Humanity)
Panelists: Aubrey de Grey (SENS Research Foundation), Gregory Fahy (Intervene Immune), Kevin Perrott (OpenCures), Sajad Zalzala (AgelessRx), Steve Horvath (UCLA)
5:55 – 6:00 PM Roundup Notes by the Chair

Day 2, Friday, August 21st

9:00 – 9:05 Welcome talk by LEAF VP Oliver Medvedik
9:05 – 9:45 Opening keynote
Brian Kennedy – National University of Singapore
Preventive Medicine in an Ageing Society (Beyond Healthcare to Health)

9:45 – 9:50 Q&A
9:50 – 10:00 Kids and Life Extension by Tim Maupin
10:00 – 11:00 Session 4: Investing in rejuvenation, part 1
David Gobel – Methuselah Foundation
We need to get back to the future – The Poison Squad vs the Nuremberg Code
Alexandra Bause – Apollo Ventures
Biotech VC meets Impact Investing with the Mission to Enhance Human Health
Premium Event
11:00 – 11:45 LEAF Panel Discussion: Role of media in engaging early adopters
Chair: Keith Comito (Lifespan.io)
Panelists: Sonia Arrison (100 Plus Capital), Pat Graziosi (Life Noggin), Greg Grinberg (ActualFood, Life+), Tim Maupin (TWOCOATS Film Production, Lifespan.io)
11:00 – 11:15 Interview with Michael Greve (Forever Healthy Foundation)
Rejuvenation Now: Sharing Vital Knowledge with the Public
11:15 – 11:45 Interview with Dr. Mair Underwood
Factors That Influence Public Views on Rejuvenation
11:45 – 12:45 Session 5: Investing in rejuvenation, part 2
Sergey Young – Longevity Vision Fund
Why Longevity Is the Next Trillion Dollar Opportunity
Javier Noris – Lifespan.io
The Longevity Impact Fund – Funding Translational Longevity Research
12:45 – 1:30 Panel Discussion: How to Overcome the Valley of Death?
Chair: Javier Noris (Lifespan.io)
Panelists: Patrick Burgermeister (Kizoo Ventures), Reason (Repair Biotechnologies), Sergio Ruiz (Methuselah Fund), Ronjon Nag (Institute R42)
1:30 – 3:00 Session 6: Targeting aging with interventions, part 1
Lewis Gruber – SIWA Therapeutics
A Comprehensive Therapy for Cancer and Other Aging-Associated and Degenerative Diseases – Attacking Senescent Cells and Cancer Cells Simultaneously
James Kirkland – Mayo Clinic
Aging, Senescent Cells, and Senolytics
Marco Quarta – Rubedo Life Sciences
Targeted senolytic systemic treatments for geriatric syndromes
3:00 – 3:40 Interview with Stanislav Skakun (BioData)
The Power of Quantified Self for Creating a Longevity Strategy
3:40 – 5:10 Session 7: Targeting aging with interventions, part 2
Reason – Repair Biotechnologies
Towards Reversal of Atherosclerosis
Hanadie Yousef – Juvena Therapeutics
Harnessing the Regenerative Secretome of Pluripotent Stem Cells to Rejuvenate Aged Tissues
Matthew O’Connor – SENS Research Foundation, Underdog
Engineering drugs for the removal of toxic metabolites with aging
5:10 – 5:15 The Last Generation to Die (trailer) by Tim Maupin
5:15 – 6:15 Session 8: Targeting aging with interventions, part 3
Peter Fedichev – GERO
Engineering rejuvenation therapeutics with AI
Joshua Mittledorf – School of Medicine, Washington University in St Louis
Are Methylation Clocks a Reliable Gauge of Anti-Aging Interventions?
6:15 – 6:20 PM Closing remarks by LEAF President Keith Comito

Lifespan Factory – On-Demand Track

Kelsey Moody – Ichor Therapeutics
2019 Workshop: Developing a Biotechnology Startup in the Rejuvenation Field
Isabelle Schiffer – Forever Healthy Foundation
Rejuvenation therapies from bench to bedside – where are we now?
Thomas Weldon – Ponce de Leon Health
How to reverse your epigenetic age now
Sajad Zalzala – AgelessRx
Phase IV Rapamycin Longevity Trial: a Paradigm Shift in Human Longevity Clinical Trials
Ronjon Nag – R42 Group
AI and Aging
Tyler Golato – Molecule
Molecule: Decentralized Drug Development and a New Financing Pathway for Longevity Therapeutics
Eric Leire – GenFlow
Genflow Biosciences: A Disruptive Approach to Longevity Therapies
Gordan Lauc – GlycanAge
Using Glycans as a Tool to Prevent Age-Related Diseases
Paul Spiegel – Eclectic Law
Beyond Retirement: A New Social Compact for the Age of Longevity
Kris Verburgh – NOVOS
The high-tech and low-tech approach to longevity: overview and ways to identify promising longevity technologies and approaches
Edward Layne – AgeMeter
Testing Functional Age and Screening for Covid-19
Greg Grinberg – ActualFood
TBA
Evan Snyder – National Institute of Health
TBA
Michael Geer – Humanity.Health
Collaborating to Increase the Healthspan of Humanity