SIWA Therapeutics are developing an immunotherapy approach to senescent cell accumulation and cancer. Their approach is really a typical monoclonal antibody product, the same sort of immunotherapy that’s used in a variety of cancer therapies. SIWA claims to have found a marker that’s on cancer cells and senescent cells because of the way the markers are produced, and therefore the monoclonal antibody can enable removal of those senescent or cancer cells.
Why we Age: Cellular Senescence
As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals, collectively known as the senescence-associated secretory phenotype (SASP), which encourages nearby cells to enter the same senescent state. Their presence causes many problems: they degrade tissue function, increase chronic inflammation, and can even eventually raise the risk of cancer and other age-related ...