Tag: Type 2 Diabetes

In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence in mice. A system tightly tied together This paper begins with a discussion of the relationship between epigenetic alterations and cellular senescence. The histone H3K4me3...

Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from the University of California, San Francisco, dare to walk an unbeaten path. Junevity pursues the ambitious goal of fixing age-related transcriptional dysregulation using short interfering...

A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells, as well as liver and fat cells, to lose their identity and malfunction [1]. Blocking this response had benefits in mouse models. The mitochondria-diabetes connection Like with many diseases, the prevalence of type 2 diabetes grows with age. Therefore,...

A new study suggests that aerobic medium-to-vigorous physical activity benefits obese and diabetic people the most when conducted in the evening hours [1]. Do you really need morning runs? Physical activity is an essential part of the longevity-conscious lifestyle and one of the best life-extending interventions currently available. However, questions remain as to what types...

Researchers have published the results of a study in Aging Cell, finding some evidence that type 2 diabetes causes accelerated aging. Later-generation clocks only What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many different kinds...

A recent study published in GeroScience has investigated whether or not a common index of metabolic syndrome can be applied to chronic kidney disease (CKD). A common metric of diabetes The triglyceride-glucose (TyG) index, which is calculated from fasting triglyceride and glucose, is used as a surrogate for insulin resistance [1], a key characteristic of...