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Tag: Telomere Attrition

An image of telomeres shortening which could lead to DNA damage.
Since its launch in 2016, Rejuvenation Technologies, located in Mountain View, California, has been developing a therapeutic to restore telomeres in humans. The company has been in stealth mode for a number of years, but there is finally some news! Reversing a decade of telomere loss in one treatment Rejuvenation Technologies has created a method...
Elderly muscle
Researchers publishing in Cell Proliferation have described factors that appear to give old muscle stem cells the ability to effectively proliferate and differentiate for a very long time. When renewal runs out Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly responsible for many...
Exercising people
Researchers publishing in BMC Medicine have found that there is a relationship between biomarkers of aging and measurements of health and mental well-being [1]. "Healthy lifestyle" is not just a phrase It is very well known that unhealthy behaviors are strongly linked to adverse health outcomes. For example, alcoholism is a significant risk factor for...
Organs
An in-depth preprint published in bioRxiv has thoroughly described how separate tissues lose proteostasis in different ways. Why we Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of age-related diseases, including Alzheimer's...
Elderly eating healthy
An extremely comprehensive review published in Food Science & Biotechnology has summarized the current state of research regarding cellular senescence and basic dietary components. An aging-focused outlook The researchers begin their paper with a discussion of aging, citing a paper that frames it in terms of homeostasis and physiological decline [1]. They discuss its primacy...
Gene pill
In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of life-extending gene therapies from science fiction to reality. Why a cytomegalovirus? The human cytomegalovirus (CMV) is widely known as an endemic virus that, while usually...