Tag: Skin

Researchers publishing in Aging Cell have found a biochemical pathway that leads skin cells to become senescent along with a potential target for future therapies. Fibroblasts have a purpose Dermal fibroblasts are common subjects in aging research, particularly in the context of senescence. These cells have a critical purpose: they are responsible for maintaining the...

A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the skin's barrier function and multiple aging biomarkers [1]. Conducted by a team from OneSkin alongside academic partners, this initial trial aimed to determine if skin...

Investigating the factors involved in skin rejuvenation processes, researchers have identified the role of hyaluronan and proteoglycan link protein 1 (HAPLN1) in restoring collagen and hyaluronic acid in aged skin [1]. The most noticeable sign of aging Skin aging, one of the most visible forms of aging, is influenced by both intrinsic and extrinsic factors....

Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don't produce the senescence-related compound p16. A necessary evil Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...

In Aging, researchers have described how the changing production of skin cells' proteins is a core part of their age-related decline. Understanding why skin cells lose their function In healthy skin, dermal fibroblasts produce the proteins needed to maintain the extracellular matrix (ECM), the network of collagen and elastin that holds soft tissues together [1]....

Scientists have found a way to reprogram fibroblasts without chemicals by culturing them on a surface with specific mechanical properties. Transplanted into aged skin, those cells boosted rejuvenation in a human tissue model [1]. We've all got skin in the game Skin aging might not be the deadliest part of organismal aging, but it certainly...