Tag: Navitoclax

In Aging Cell, researchers have published their findings that mice exposed to influenza experience long-term consequences that can be partially ameliorated with senolytics. Post-viral syndromes Long before the spread of the SARS-CoV-2 virus that causes COVID-19, it had been well-established that viral lung diseases such as influenza lead to lasting damage [1, 2]. Increased risks...

In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go. Finding the right nanoparticle Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...

A team of researchers have explained in Aging how multiple compounds that target the BCL-2 protein family are considerably more effective against senescent cells than each compound by itself [1]. The limitations of existing senolytics The researchers begin their paper with a familiar discussion of senescent cells and their dangers, citing a 2019 paper outlining...

In their publication in eLife Sciences, researchers at Newcastle University in the UK have illustrated how radiation-induced damage can be somewhat ameliorated with senolytics. These researchers focused on navitoclax along with the well-known combination of dasatinib and quercetin. A focus on cancer survivors The researchers begin this paper with a discussion of cancer treatments. They...

Scientists have shown that clearing senescent neural precursor cells with the senolytic drug navitoclax reverses the age-related decline in neurogenesis and improves spatial memory in mice [1]. Not to be replaced The brain is an organ of special concern for geroscientists. It is theorized that we might soon be able to replace many aging organs,...