Tag: mRNA

In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the FGF18 protein with healthy cartilage and joints [1]. Problems with the gene responsible for FGF18 lead to osteoarthritis [2], and it has been found to...

Katalin Karikó and Drew Weissman received this year’s Nobel Prize in Physiology or Medicine for a groundbreaking discovery that facilitated the development of mRNA vaccines and can be relevant to future anti-aging therapies. A crucial discovery The COVID-19 pandemic was one of the biggest health challenges that humanity has ever seen. At its dawn, things...

Since its launch in 2016, Rejuvenation Technologies, located in Mountain View, California, has been developing a therapeutic to restore telomeres in humans. The company has been in stealth mode for a number of years, but there is finally some news! Reversing a decade of telomere loss in one treatment Rejuvenation Technologies has created a method...

Research published yesterday in Nature has described one way in which RNA sequencing changes in the cell with age and how this may be linked to lifespan. Transcriptional elongation Transcriptional elongation is a fundamental biological process, as it affects the basic steps involved in the production of RNA, which is responsible for executing the instructions...

Scientists have demonstrated that extracellular vesicles loaded with mRNA coding for collagen production can be easily produced and delivered into aging fibroblasts in vitro and in vivo, boosting collagen levels and eliminating signs of skin aging in mice [1]. Superior delivery method Finding a good way to deliver molecular cargo into cells is important. Some...

Publishing in Aging five months after their panel discussion in Copenhagen, many well-known researchers have explained their reasons for wishing to add new hallmarks of aging to the existing paradigm. A new addition to an old paradigm The Hallmarks of Aging, a well-cited and well-respected 2013 paper [1], categorizes the myriad aspects of aging into...