Tag: Mitochondria

Financed by Lifespan.io's crowdfunding efforts, SENS Research Foundation has engaged in fruitful research into ways of dealing with mitochondrial dysfunction, the gradual loss of function of our cells' power plants. Here, the organization reports its successes in handling this aspect of aging. The cellular machinery and higher-level structures of our bodies inevitably damage themselves as...

Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn't work Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause...

Scientists have discovered that formerly obese mice that became leaner have greatly improved energy efficiency, which might be preventing their complete return to normal weight [1].  Why is it so hard to lose the last few pounds? People attempting to lose weight often feel like their own bodies are fighting them, as shedding additional pounds...

A paper published in Experimental Gerontology has provided a fresh and detailed look at the effects of oxidative stress on longevity. Revisiting an old theory The free radical theory of aging, which purports that reactive oxygen species (ROS) are the core driver of aging, was developed all the way back in 1956 [1] and expanded...

Researchers publishing in Cell Stem Cell have found that the mitochondrial protein OPA1 is an integral, regulatory part of muscle stem cell activation, the process by which muscle stem cells proliferate and become active muscle tissue (myogenesis) [1]. Another piece of the puzzle We have recently reported on the effects of mitochondrial fusion and fission...

Scientists have drastically improved various symptoms of atherosclerosis in mice by precisely targeting mitochondria with a plant-derived antioxidant [1]. Age-related and deadly Atherosclerosis, the accumulation of plaques on arterial walls, is one of the deadliest age-related diseases. Atherosclerotic plaques, which consist mostly of cholesterol and fat, can impede blood flow in the artery or burst,...