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Tag: Loss of Proteostasis

Solving brain puzzle
A recent study, led by the University of Cincinnati in collaboration with the Karolinska Institute in Sweden, challenges the popular amyloid hypothesis that has dominated Alzheimer’s research for decades. Amyloid accumulation may be the consequence, not the cause Over 100 years ago, Alois Alzheimer originally identified amyloid-beta plaques in the brains of people with the...
Lung branches
A new review published in the American Journal of Respiratory Cell and Molecular Biology discusses the causes of, and potential treatments for, idiopathic pulmonary fibrosis (IPF). Fibrosis, but not focused on fibroblasts In the lungs, the trachea (airway) breaks out into a tree-like system of nodes. Each branch ends in alveoli, which are responsible for...
Saunas can activate heat shock proteins and may be a potential way to improve health and potentially, longevity.
There are a few reasons to consider including sauna use as part of your personal health and longevity strategy. What is a sauna? The word sauna comes from the Finnish language, and it means an earth or snow pit. While Finnish saunas today are typically log-walled, wooden paneled, or even tiled structures, these modern forms...
A depiction of NAD on a black background
Aging is accompanied by the loss of proteostasis, the accumulation of misfolded proteins and their amyloid aggregates, and mitochondrial dysfunction, which is partially characterized by the loss of mitochondrial homeostasis, the delicate balance that mitochondria need in order to produce energy without polluting the body with excessive amounts of free radicals. The hallmarks of aging...
CGI of protein structures
Alphabet's subsidiary DeepMind has all but solved the problem of predicting a protein’s shape from its amino acid sequence. DeepMind’s program AlphaFold reached close to 90% average accuracy, which is comparable to experimental structural analysis. Proteins: life's multitool Proteins are the primary tool with which organisms do stuff. They are indispensable for most biological processes....
Cerebral blood vessels
A new study conducted by researchers from Germany and the UK has shown that accumulation of medin, an amyloid of the protein MFG-E8, leads to cerebrovascular (brain blood vessel) disease in wild-type mice [1]. Why we Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein building machinery of the cell and...