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Tag: Loss of proteostasis

August 04, 2020
A group of scientists have shown that the SIRT2 protein increases the accumulation of amyloid beta, a known marker of Alzheimer's disease (AD), in the brains of mice. They propose a mechanism underlying this phenomenon and demonstrate that inhibiting SIRT2 ameliorates AD-associated cognitive decline in mice [1]. AD is one of the most devastating age-related...
June 24, 2020
In a recent study, researchers from the Buck Institute have shown that cellular senescence, one of the hallmarks of aging, is partially responsible for Alzheimer's disease. Cellular SenescenceAs your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do not divide or support the tissues of which they are...
April 23, 2020
Last week featured Cecilia Brunello discussing proteostasis; for this week's trivia episode of X10, she created a related quiz for Nicola and Giuliano to answer. Are they, in fact, pros at proteostasis? (adsbygoogle = window.adsbygoogle || []).push({});
April 09, 2020
In this talk episode, Nicola, Veera, and Cecilia Brunello of Helsinki University discuss loss of proteostasis, the primary hallmark of aging that leads to Alzheimer's and other deadly disorders. (adsbygoogle = window.adsbygoogle || []).push({});
February 13, 2020
On this informative episode of X10, Giuliano explains proteins and how they misfold, causing the hallmark of aging known as loss of proteostasis- which leads to Alzheimer's disease and other dangerous diseases.  (adsbygoogle = window.adsbygoogle || []).push({});
August 29, 2019
In a recent study, a team of researchers has discovered that a naturally occurring protein called Lipocalin-type prostaglandin D synthase (L-PGDS) prevents, and can destroy, the protein aggregates associated with Alzheimer's disease. Surprisingly common and with critical functions L-PGDS is a common protein, second only to albumin, in the human brain. It provides several critical...