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Tag: Loss of Proteostasis

Elderly Blood Draw
Published in GeroScience, a groundbreaking study from the renowned Conboy lab has confirmed that plasma dilution leads to systemic rejuvenation against multiple proteomic aspects of aging in human beings. Systemic molecular excess This paper takes the view that much of aging is driven by systemic molecular excess. Signaling molecules, antibodies, and toxins, which gradually accumulate...
Lewy bodies
A team of researchers publishing in Nature Communications has described nanobodies that can destroy the α-synuclein aggregates that characterize Lewy bodies, which are associated with dementia and Parkinson's disease [1]. What are nanobodies? Traditional antibody therapies, while promising in some studies, are too large to enter cells in order to affect the aggregates there [2]....
Organs
An in-depth preprint published in bioRxiv has thoroughly described how separate tissues lose proteostasis in different ways. Why we Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of age-related diseases, including Alzheimer's...
Lab mouse in hand
Researchers publishing in Aging have found that the anti-malarial drug chloroquine increases lifespan in male NRMI mice. The NRMI, like the Black 6, is a standard breed widely used in research, and these mice were not directly genetically modified. Substantial positive lifespan effects We have previously reported a study showing that choloroquine increases longevity in...
Fly eyes
Increasing an important protein regulator improves the lifespan of Drosophila flies, according to a new paper published in Aging. Found in both animals and plants As the researchers explain, phosphatidylethanolamine-binding proteins (PEBPs) are present in both plant and animal cells. These proteins are critical to multiple fundamental cellular functions, including in cancer cells [1,2]. While...
Common Aggregate
Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related neurological disorders. Three classes of pathology, one protein fragment The authors of this study list three different classes of neurodegenerative protein disorders: TDP-43 proteinopathies, such...

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