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Tag: Loss of proteostasis

February 13, 2020
On this informative episode of X10, Giuliano explains proteins and how they misfold, causing the hallmark of aging known as loss of proteostasis- which leads to Alzheimer's disease and other dangerous diseases.  (adsbygoogle = window.adsbygoogle || []).push({});
August 29, 2019
In a recent study, a team of researchers has discovered that a naturally occurring protein called Lipocalin-type prostaglandin D synthase (L-PGDS) prevents, and can destroy, the protein aggregates associated with Alzheimer's disease. Surprisingly common and with critical functions L-PGDS is a common protein, second only to albumin, in the human brain. It provides several critical...
July 26, 2019
Researchers from the Beijing Institute of Brain Disorders have discovered a new method of using exosomes to deliver aptamers that prevent the accumulation of α-synuclein aggregates, which are the cause of Parkinson's disease [1]. α-Synuclein Aggregates Like Alzheimer's, Parkinson's disease is characterized by protein aggregation caused by a loss of proteostasis, one of the hallmarks...
June 28, 2019
A new mouse study highlights the proteins responsible for LC3-associated endocytosis (LANDO), an autophagy process that is involved in degrading β-amyloid, the principal substance associated with Alzheimer's disease. Proteostasis Proteins in the human brain can form misfolded, non-functional, and toxic clumps known as aggregates. Preventing these aggregates from forming, and removing them when they do,...
June 12, 2019
Today, we want to point out a new publication that recently appeared in the Science Translational Medicine journal, as its authors have discovered a new mechanism by which the brain protects itself from the harmful α-synuclein protein aggregates associated with Parkinson's and that may open the door to new therapies against these conditions. To understand...
February 28, 2019
In order to remain healthy and functional, cells have a number of maintenance systems that help them to dispose of metabolic waste and unwanted proteins. Autophagy is perhaps the best-known example of how cells purge their waste, and another is the ubiquitin-proteasome system (UPS). Researchers are working on ways to boost the activity of the...