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Tag: Loss of Proteostasis

A depiction of NAD on a black background
February 05, 2021
Aging is accompanied by the loss of proteostasis, the accumulation of misfolded proteins and their amyloid aggregates, and mitochondrial dysfunction, which is partially characterized by the loss of mitochondrial homeostasis, the delicate balance that mitochondria need in order to produce energy without polluting the body with excessive amounts of free radicals. The hallmarks of aging...
CGI of protein structures
December 08, 2020
Alphabet's subsidiary DeepMind has all but solved the problem of predicting a protein’s shape from its amino acid sequence. DeepMind’s program AlphaFold reached close to 90% average accuracy, which is comparable to experimental structural analysis. Proteins: life's multitool Proteins are the primary tool with which organisms do stuff. They are indispensable for most biological processes....
Cerebral blood vessels
October 02, 2020
A new study conducted by researchers from Germany and the UK has shown that accumulation of medin, an amyloid of the protein MFG-E8, leads to cerebrovascular (brain blood vessel) disease in wild-type mice [1]. Loss of ProteostasisThe loss of proteostasis is the failure of the protein building machinery of the cell and the accumulation of...
August 04, 2020
A group of scientists have shown that the SIRT2 protein increases the accumulation of amyloid beta, a known marker of Alzheimer's disease (AD), in the brains of mice. They propose a mechanism underlying this phenomenon and demonstrate that inhibiting SIRT2 ameliorates AD-associated cognitive decline in mice [1]. AD is one of the most devastating age-related...
Alzheimer's disease
June 24, 2020
In a recent study, researchers from the Buck Institute have shown that cellular senescence, one of the hallmarks of aging, is partially responsible for Alzheimer's disease. Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially...
X10 Proteostasis Trivia
April 23, 2020
Last week featured Cecilia Brunello discussing proteostasis; for this week's trivia episode of X10, she created a related quiz for Nicola and Giuliano to answer. Are they, in fact, pros at proteostasis? HELP SPREAD THE WORD Please connect with us on social media, like and share our content, and help us build grass-roots support for...