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Tag: Loss of Proteostasis

Fly eyes
Increasing an important protein regulator improves the lifespan of Drosophila flies, according to a new paper published in Aging. Found in both animals and plants As the researchers explain, phosphatidylethanolamine-binding proteins (PEBPs) are present in both plant and animal cells. These proteins are critical to multiple fundamental cellular functions, including in cancer cells [1,2]. While...
Common Aggregate
Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related neurological disorders. Three classes of pathology, one protein fragment The authors of this study list three different classes of neurodegenerative protein disorders: TDP-43 proteinopathies, such...
Amyloid tangles
A team of researchers publishing in the Nature publication Molecular Psychiatry has described how a newly discovered interaction of amyloid beta (Aβ) is being used in the development of a vaccine for Alzheimer's disease. A specific antibody for truncated Aβ The biochemistry of Alzheimer's is extremely complicated. Aβ is not always one molecule with a...
Links
Researchers publishing in Aging have discovered that an energy metabolism compound is associated with a protein that suppresses amyloid beta in a mouse model of Alzheimer's. The compounds involved The researchers describe nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) as a key co-factor for energy metabolism. This compound is involved in creating NAD+, which is essential in...
Balanced stones
Scientists have demonstrated that “the Alzheimer’s allele” APOE e4 helps cognition earlier in life prior to the onset of the disease [1]. This might point at a possible reason for some aspects of aging. What makes us stronger kills us later The risk of developing Alzheimer's, one of the deadliest age-related diseases, is considerably elevated...
Protein
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new research [1]. Proofreading proteins The loss of proteostasis is one of the hallmarks of aging. However, much of the research on the topic has focused...