Tag: iPSCs

Scientists have developed a novel multicellular integrated brain model to study neurological diseases, incorporating all six major brain cell types derived from patient-specific induced pluripotent stem cells (iPSCs) [1]. Beyond organoids Organoids, tiny lab-grown patches of tissue, are a promising tool for accelerating medical research [2]. They sit a step above cultured cells, being able...

In Cell Stem Cell, researchers have described how genetically engineered microglia can be used to deliver therapeutic proteins to the brain. The blood-brain barrier Delivering therapeutic compounds to the brain has a concern that is absent for other organs: the blood-brain barrier (BBB), which retains strict controls over the kinds of compounds that can reach...

In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice. A new era of organ replacement In their introduction, the researchers discuss the well-known problems with insulin injections to treat Type 1 diabetes: the sort of constant monitoring that is...

German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells. Following a success with rhesus monkeys, they have obtained approval for a human trial [1]. Wear and tear As one of the most hard-working tissues in the body, the heart muscle is subject to incessant wear and tear due to...

Researchers are keeping a bank of induced pluripotent stem cells (iPSCs) derived from centenarians and their descendants. They describe the purpose of this bank and its uses in Aging Cell. A category of their own Centenarians don't merely live for a hundred years; they spend more time in good health (healthspan) than other people. This...

Scientists have successfully used heart muscle cells created from induced pluripotent stem cells to counter the deleterious effects of heart attack in non-human primates. Reprogrammed cells for heart regeneration Yamanaka Factors - Opportunities for RejuvenationDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic...