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Tag: Genetics

October 22, 2020
A new analysis has revealed a core set of genes involved in aging in both humans and mice. Together with a broader set of age-related genes assembled by the study [1], this resource will serve as a launching point for further investigations of the mechanisms behind aging and age-related diseases. The heart of the matter...
July 07, 2020
A group of scientists from Colorado State University has discovered that repetitive elements (REs) in our DNA increase with aging and react to known longevity-promoting interventions [1]. Are REs genomic parasites? At the dawn of genomic research scientists were stunned to learn that as much as 95% of our genome is non-coding: it does not...
June 30, 2020
By using a large UK health databank and advanced methods of statistical analysis, scientists have discovered genetic ties between various age-related diseases and proposed several candidate drugs for upstream intervention. Building age-of-onset profiles of diseases The very fact that multitudes of age-related diseases (ARDs) exist alludes to more than just a coincidence. One of the...
August 31, 2019
The Journal Club on August 27 was hosted by Dr. Oliver Medvedik and special guest Dr. Alexander Tyshkovskiy, who works at the Gladyshev at Brigham and Women’s Hospital, Harvard Medical School, Boston. The topic was the recent paper "Identification and Application of Gene Expression Signatures Associated with Lifespan Extension" published in Cell Metabolism. This study...
July 23, 2019
Recently, we had the opportunity to interview Professor George Church, a well-known geneticist and rejuvenation expert whom we have previously interviewed. Prof. Church's company, Rejuvenate Bio, will be launching a clinical trial to test a rejuvenation therapy in dogs this fall. In your recent paper on enabling large-scale genome editing, you talked about manipulating endogenous...
February 27, 2019
The February Journal Club focused on the recent paper "Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances". Hosted by Dr. Oliver Medvedik, we were joined by study author Dr. Peter Joshi from the University of Edinburgh, UK, who guides us through this fascinating genomics study of human...