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Tag: Genetics

Electrical Cells
A paper published today in Nature Metabolism has described a method of genetically engineering cells to respond to electrical stimuli, allowing for on-demand gene expression. Finding a better trigger Despite its futuristic outlook, this line of research is built upon previous work. The idea of an implantable gene switch to command cells in order to...
DNA
Researchers have analyzed the activity of genes in the livers, kidneys, and brains of over a hundred mammals and found genes that are consistently associated with longevity [1]. The search for longevity-associated genes Between the shortest-living and the longest-living mammal, there is a more than 100-fold difference in lifespan. This natural difference may be key...
Running calico mouse
Scientists have shown that a longevity-associated variant of the BPIFB4 gene protects cardiovascular health, including when introduced by viral vectors [1]. All you need is LAV Among age-related pathologies, cardiovascular disease is the most prolific killer, claiming about 700,000 victims every year in the US alone and as many as 18 million worldwide. However, some...
100th birthday cake
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain extreme longevity [1]. Genetics can be friend or foe Centenarians are people who have lived for at least a century. Not only do these genetically...
Bowhead whale
A preprint published in bioRxiv has partially explained the lifespan of the bowhead whale through its duplication of CDKN2C, which regulates how cells divide. Peto's paradox It would be logical for longer-lived animals to be more susceptible to cancer than shorter-lived animals over time, as they have longer to develop the mutations that lead to...
Genetic mutation
A research paper published in Nature Medicine has shown the results of a broad investigation into gene variants associated with healthspan [1]. Genome-wide association studies A genome-wide association study is an effort to use enormous databases and computational analysis to examine the genetic causes of disease [2]. Previous studies have evaluated the effects of genes...