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Tag: Genetics

Gut bacteria
Most of the genetic changes associated with increasing age disappear in the absence of gut bacteria, according to a new fruit fly study [1]. It’s a pretty surprising finding, and while there are some important implications, it’s also a bit challenging to interpret. A flat aging line The experiment itself was relatively straightforward. A team...
Gabriela Bunu
At Ending Age-Related Diseases 2020, Gabriela Bunu of the Institute of Biochemistry, Romanian Academy discussed SynergyAge, a database of the interactions of longevity-associated genes. This database is designed to calculate which genes are responsible for longevity, and which genes have been associated with a lack of longevity, in several distinct organisms, including mice. Multiple biochemical...
DNA data
A new analysis has revealed a core set of genes involved in aging in both humans and mice. Together with a broader set of age-related genes assembled by the study [1], this resource will serve as a launching point for further investigations of the mechanisms behind aging and age-related diseases. The heart of the matter...
Spam
A group of scientists from Colorado State University has discovered that repetitive elements (REs) in our DNA increase with aging and react to known longevity-promoting interventions [1]. Are REs genomic parasites? At the dawn of genomic research scientists were stunned to learn that as much as 95% of our genome is non-coding: it does not...
By using a large UK health databank and advanced methods of statistical analysis, scientists have discovered genetic ties between various age-related diseases and proposed several candidate drugs for upstream intervention. Building age-of-onset profiles of diseases The very fact that multitudes of age-related diseases (ARDs) exist alludes to more than just a coincidence. One of the...
The Journal Club on August 27 was hosted by Dr. Oliver Medvedik and special guest Dr. Alexander Tyshkovskiy, who works at the Gladyshev at Brigham and Women’s Hospital, Harvard Medical School, Boston. The topic was the recent paper "Identification and Application of Gene Expression Signatures Associated with Lifespan Extension" published in Cell Metabolism. This study...