Tag: Frailty

In Aging Cell, a team of researchers has described how the health of skin fibroblasts relates to physical and functional ability. Frailty, capacity, and skin cells This paper begins with an explanation of how frailty and capacity are defined. The World Health Organization defines it as an overall state of reduced strength, endurance, and physiogical...

In a recent study, researchers investigated how restricting dietary methionine and inhibiting the tyrosine degradation pathway affects healthspan in aged mice. While affecting tyrosine didn’t show any benefits, methionine restriction improved many, but not all, measures of healthspan, including frailty, pathological disease burden, and neuromuscular function [1]. Aging of metabolism Changes in metabolism accompany aging...

In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to the clinic As a mitochondria-affecting antioxidant peptide, elamipretide has been, and continues to be, the subject of multiple investigations. As far back as 2004, researchers...

A research paper published in Aging explored a link between breast cancer, hematopoietic cell transplants (HCTs), an increase in physical frailty, and cellular senescence. Treatment comes at a cost HCTs and breast cancer treatment are lifesaving procedures. However, chemotherapy in breast cancer sharply increases p16INK4a, a key biomarker of cellular senescence [1], and HCTs are...

Scientists have found that older people currently retain more youthful abilities than people who were the same age did in previous decades [1]. How miserable are we? Recent decades have seen leaps in average life expectancy. However, those mostly stem from successes in curbing childhood mortality and infectious diseases. The gains in later life have...

A placebo-controlled Phase 1/2 trial conducted in East Shanghai has found that administering umbilical cord-derived mesenchymal stem cells reduces frailty in older people. Stem cells against frailty These researchers begin by defining frailty as "a state of heightened vulnerability to potential stressors as a consequence of reduction in physiological reserves across multiple systems" [1]. This...