Tag: Epigenetic Alterations

Researchers publishing in the Nature journal Cell Discovery have described how the age-related attenuation of a key metabolic axis causes human adipose-derived stem cells (hASCs) to lose functional capabilities. Pinpointing the loss of function This paper begins by highlighting a core problem of using self-derived (autologous) stem cells for treatments in older people: the cells...

In Aging Cell, researchers have described core genes that apply to a wide variety of species and appear to be causal drivers of aging. Looking for signals in the noise Introducing their study, the researchers note that gene expression changes are difficult to interpret because they occur across a panoply of genes and the strongest...

In Aging Cell, researchers have reported that chromatin demethylation allows SASP compounds to be more easily expressed. Chromatin and gene expression Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals, collectively known...

Researchers have analyzed molecular patterns from different tissues obtained from over 700 people and learned that smoking acts as an aging accelerator and involves molecular changes in tissues beyond those directly exposed to cigarette smoke [1]. Millions of preventable deaths Despite campaigns aimed at the reduction of tobacco smoking, it is still a very common...

In Aging Cell, researchers have found that exposing ordinary Black 6 mice to a more natural environment accelerates rather than slows the aging of their livers. When natural doesn't mean better It is a well-known fact that laboratory animals live in controlled conditions beyond that of wild animals or even most pets. Temperature and food...

Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging [1]. XX and XY It is widely known that women live longer than men [2]. Women also show differences in cognitive aging [3]. "In typical...