July 15, 2022
Researchers have shown that even mild SARS-CoV-2 infection can cause lingering neurological symptoms. These findings might shed light on the infamous "long COVID" [1]. Mild doesn't mean harmless COVID survivors sometimes experience cognitive symptoms, such as “brain fog”, that can linger for months. Those symptoms can be debilitating, affecting work performance and learning, and they...
March 21, 2022
A research paper that has just been peer reviewed and published in Nature has described how disrupting an immune pathway that is upregulated in aging decreases the lethality of COVID-19 in a mouse model. Mice with COVID-19 As the researchers explain, normal mice do not use the same angiotensin converting enzyme 2 (ACE2) as humans,...
July 27, 2021
We recently caught up with Dr. Aubrey de Grey and Michael Rae from SENS Research Foundation (SRF) about the landscape in the field. We asked them two simple questions, and they joined forces to give us their combined insights. Lifespan.io: First, do you think we can defeat aging? Of course I think we can defeat...
July 22, 2021
Researchers have used a big data approach to disentangle cellular and physiological changes that are specific to COVID-19 from those caused by aging [1]. Identifying these improves our understanding of the disease and may help explain why COVID-19 has a more severe effect on older people. A tangled skein The enormous impact of COVID-19 around...
June 09, 2021
New research published in the journal Science has shown that the spike protein of SARS-CoV-2, the virus that causes COVID-19, causes senescent cells to secrete more of the senescence-associated secretory phenotype (SASP), causing hyperinflammation and weakening the body's defenses against viruses. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent....
January 20, 2021
New research published in Aging has analyzed the telomeres of patients hospitalized due to COVID-19. Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet they consist of repetitions of a single sequence: TTAGGG. Telomeres do not code for proteins, but...
