Tag: Cellular Senescence

Researchers publishing in Nature Aging have discovered how Alzheimer's-related protein aggregates are also related to senescent cells and osteoporosis. Beyond the brain Why We Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of...

Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning is normal During brain development, the resident immune cells of the brain (microglia) prune unneeded synapses as a form of maintenance. This is normally a...

Researchers have discovered how and why α-ketoglutaric acid (AKG) affects cellular senescence and how a small molecule may be useful in affecting this process. They published their findings in Cell Reports. A crucial molecule AKG is a major part of multiple fundamental metabolic processes, including the Krebs cycle that mitochondria use to generate energy, and...

In Aging Cell, researchers have published their findings that mice exposed to influenza experience long-term consequences that can be partially ameliorated with senolytics. Post-viral syndromes Long before the spread of the SARS-CoV-2 virus that causes COVID-19, it had been well-established that viral lung diseases such as influenza lead to lasting damage [1, 2]. Increased risks...

Researchers publishing in Cell Reports Medicine have taken a look at what causes CRISPR/Cas9 gene-editing technology to drive cells senescent and investigated a potential method of preventing it. Breaking and repairing DNA Genetic engineering of living cells through CRISPR/Cas9 technology requires three things to occur. The DNA must be disconnected in a double-strand break, new...

In a recent study that included data from humans, mice, and cell culture experiments, researchers demonstrated that gut microbes and their metabolites can profoundly influence the senescence of endothelial cells. They also explored the molecular processes underlying these changes [1]. Senescence in the blood vessels Endothelial cells line the inner surfaces of blood vessels, and...