Tag: Cardiovascular Disease

The European Heart Journal has published a review of what happens to the human heart as it ages, noting the cellular effects of mitochondrial dysfunction and cellular senescence along with more visible changes such as hypertrophy and fibrosis. A constantly working organ The reviewers begin this paper by noting the constant work of the heart,...

Researchers publishing in Aging have used Mendelian randomization to conclude that the inflammatory factor IL6 causes increased mortality and that its circulating receptor, IL6R, decreases it. Looking for a proof of danger Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection...

A new observational study suggests that men need more than twice as much exercise as women do to achieve the same level of reduction in the risk of cardiovascular heart disease [1]. Understanding sex differences In recent years, scientists have questioned how much exercise is needed for tangible health benefits. Current guidelines from the American...

A recent study investigated the roles of brown adipose tissue and a lipid-controlling hormone, 12,13-diHOME, in cardiac health. The researchers examined the molecular mechanisms behind 12,13-diHOME's effects on the hearts of aged mice [1]. The aging heart Aging leads to many cardiovascular system-related changes, which are connected to disruptions in Ca2+ metabolism [2]. Similarly, brown...

In Cell Reports Medicine, researchers have published a detailed review on the relationship between cardiovascular disease and the age-related inflammation known as inflammaging. The immune system itself ages Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection or obvious injury. In...

A study published in JAMA Internal Medicine suggests that a higher intake of butter is associated with increased mortality while a higher intake of plant-based oils is associated with reduced mortality [1]. Fats: the good, the bad, and the ugly Previous research has found that not all dietary fats are created equal. Results of different studies...