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Tag: Caloric Restriction

Mouse maze
A new study published in Neurobiology of Aging has shown that neither caloric restriction nor intermittent fasting improve late-life cognition in genetically diverse mice, but the effect depends on genetic composition [1]. Eat less, think better? Dietary interventions are known to have potential to extend lifespan and delay age-associated diseases, at least in animal models....
Small healthy meal
A new study published in Mechanisms of Aging and Development has shown that caloric restriction effectively restores T cell abundance in aged mice [1]. Is it really just about getting fewer calories? Caloric restriction has become a well-known anti-aging intervention, as it can reverse several hallmarks of aging and extend lifespan in different animal models....
Mouse feeding
In a new study published in Science, researchers show that caloric restriction and time-restricted feeding have an additive effect on lifespan in mice [1]. A well-known intervention Caloric restriction is considered the first intervention to reliably show that aging is a malleable phenomenon. The first trials were conducted on rats back in the 1930s and...
Many lab mice
A new study published in Nature Communications has found that rapamycin, which is often considered to be a calorie restriction mimetic, has different and additive effects to caloric restriction in muscle tissue. The role of mTORC1 Mammalian target of rapamycin complex 1 (mTORC1) is a well-known component of fundamental nutrient sensing pathways whose dysregulation is...
Psoralea corylifolia
A new publication in Nature Communications has revealed that corylin, which is derived from the Chinese herb Psoralea corylifolia, increases the lifespan of model organisms through well-known pathways of aging. Finding corylin This study did not begin with an examination of corylin or even a look at this particular herb. Instead, the researchers examined multiple...
Small mouse big mouse
Publishing in Aging, researchers from the Chengdu Jinjiang Hospital in China have discovered that caloric restriction is less effective on mice previously fed a high-calorie diet. Well-known effects In their introduction, the researchers discuss what caloric restriction is known to do, citing papers that show its effects on autophagy [1], inflammation [2], nutrient sensing [3],...

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