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Tag: Caloric Restriction

Time restricted eating
Scientists have shown in mice that long-term caloric restriction can attenuate age-related immunosenescence on par with antibody-mediated clearance of senescent T-cells. On top of that, caloric restriction predictably improved glucose tolerance and lowered inflammation [1]. Senescent cells: inflamed and half-dead Immunosenescence is an umbrella term for a variety of largely detrimental changes that our immune...
AKG may be a useful supplement for slowing down aging.
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. What is alpha-ketoglutarate? AKG is a naturally occurring endogenous intermediary metabolite and part of the Krebs cycle, which means...
Smell of Food
Experiments by researchers in China and the US have shown that the smell of food is enough to reduce the lifespan gains caused by dietary restriction in nematodes. By unraveling the genetic and neurological network behind this, the team found evidence that the same might hold true in mammals. Dietary restriction is more than a...
X10 Intermittent Fasting
In this episode of X10, we discuss the concept of intermittent fasting: what it is, how it differs from caloric restriction, whether or not it can make you live longer or healthier, and the methods of going about it. Script This is part of a series of videos on diet and longevity. Last time, we...
Many foods contain selenium such as nuts, eggs, mushrooms, and some meats.
A recent study has shown that mice given selenium supplements were protected against the effects of a high-fat diet, similar to mice with a restricted methonine intake. Methonine restriction and caloric restriction It is well known among the longevity community that restricting calories leads to health benefits, and the practice of caloric restriction (CR) is...
X10 Caloric Restriction Thumbnail
In this episode of X10, we discuss the practice of caloric restriction along with its effects, which involve the TOR signaling pathway, epigenetic alterations, and DNA repair.  Sources Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. (2009) Caloric restriction delays...