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Tag: Caloric restriction

December 13, 2019
Building upon previous studies, a new study has unearthed critical facts about the basic biology behind the TORC1 pathway, identifying how caloric restriction leads to a chain of effects that activate the protein Maf1, repress RNA transcription, and slow genomic instability, which is one of the primary hallmarks of aging. A long chain of causes...
November 22, 2019
A recent study published in Cell Stem Cell shows that fasting and metformin are effective in a mouse model of demyelination, which is caused in humans by such disorders as multiple sclerosis. Myelin, demyelination, and remyelination Myelin, a substance rich in beneficial proteins and fats, is an insulator and protector of nerve cells and helps...
July 24, 2019
Researchers have discovered a new drug that targets the mTOR pathway, which is involved in aging and metabolism. It could function as a caloric restriction mimetic, bringing about similar health benefits. The mTOR pathway The mechanistic target of rapamycin (mTOR) pathway is a part of metabolism and is one of the four major pathways that...
November 28, 2018
Today, we want to discuss this review published in the journal Science, as it provides a whistle-stop tour of caloric restriction, intermittent fasting, and time-restricted feeding. There is a considerable amount of data supporting the effects of caloric restriction and similar dietary approaches on both health and lifespan in multiple species. In general, the more...
November 13, 2018
Researchers from the Kapahi Lab at the Buck Institute for Research on Aging have shown in a new study that increased intestinal permeability is caused by the age-related loss of epithelial cells that form the gut membrane [1]. As we age, the integrity of the gut membrane declines, and it becomes more permeable; this is...
June 14, 2018
Hypertension is an increasingly encountered condition in modern society, as sedentary lifestyles, poor diet, and other unhealthy lifestyle choices are becoming more prevalent. The aging processes generally cause our blood pressure to rise, as they steadily clog our arteries, stiffen blood vessels, and cause our hearts to work harder to get blood to all our...