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Tag: Caloric restriction

September 10, 2020
A short-term caloric restriction diet enhanced a DNA repair process known as non-homologous end joining. These results may partially explain how caloric restriction and similar diets increase lifespan and healthspan in a wide range of organisms. Eat less, live longer Caloric restriction – that is, reduced caloric intake without malnutrition – is one of the...
September 07, 2020
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. History of alpha-ketoglutarate Alpha-ketoglutarate (AKG) was discovered in 1937 by Hans Adolf Krebs and William Arthur Johnson at the...
August 05, 2020
Researchers have taken a look at how caloric restriction seems to improve intestinal stem cell function in a new open-access study. Inflammaging is a precursor of age-related diseases The lining of the intestines helps to prevent the entry of microbes and unwanted molecules into the bloodstream beyond; however, as we age, the integrity of this...
December 13, 2019
Building upon previous studies, a new study has unearthed critical facts about the basic biology behind the TORC1 pathway, identifying how caloric restriction leads to a chain of effects that activate the protein Maf1, repress RNA transcription, and slow genomic instability, which is one of the primary hallmarks of aging. A long chain of causes...
November 22, 2019
A recent study published in Cell Stem Cell shows that fasting and metformin are effective in a mouse model of demyelination, which is caused in humans by such disorders as multiple sclerosis. Myelin, demyelination, and remyelination Myelin, a substance rich in beneficial proteins and fats, is an insulator and protector of nerve cells and helps...
July 24, 2019
Researchers have discovered a new drug that targets the mTOR pathway, which is involved in aging and metabolism. It could function as a caloric restriction mimetic, bringing about similar health benefits. The mTOR pathway The mechanistic target of rapamycin (mTOR) pathway is a part of metabolism and is one of the four major pathways that...