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Tag: Caloric Restriction

Macaques
In one of the first studies of its kind, the popular senolytic combination, administered systematically for six months, produced several health benefits in these animals. Some effects were augmented by caloric restriction [1]. Coup de grΓ’ce for cells The combination of the drug dasatinib and the flavonoid quercetin, also known as D+Q, is one of...
Food clock
In a paper published in Nature Aging, researchers have shown that caloric restriction modestly slows down the pace of aging in healthy young people as measured by one of the DNA methylation clocks [1]. CALERIE design A plethora of animal data has shown beneficial effects of caloric restriction for health and longevity. Human trials, albeit...
Flatworm
In a preprint paper, researchers have evaluated the effect of caloric restriction on two long-lived planarian species in various environments that mimic the stochasticity of the real world [1]. Does the theory hold? According to a theory that is largely based on plentiful data from model organisms, restricted food intake (caloric restriction) extends animals’ lifespans...
Infectious disease
A meta-analysis published in GeroScience has shown that the well-studied drug rapamycin has positive effects on infection in mice, but dietary restriction seems to worsen the problem. Aging, immunity, and interventions This paper begins with the well-known information that aging impairs the immune system, harming its effectiveness against infectious diseases [1] while causing systemic inflammation...
Mouse maze
A new study published in Neurobiology of Aging has shown that neither caloric restriction nor intermittent fasting improve late-life cognition in genetically diverse mice, but the effect depends on genetic composition [1]. Eat less, think better? Dietary interventions are known to have potential to extend lifespan and delay age-associated diseases, at least in animal models....
Small healthy meal
A new study published in Mechanisms of Aging and Development has shown that caloric restriction effectively restores T cell abundance in aged mice [1]. Is it really just about getting fewer calories? Caloric restriction has become a well-known anti-aging intervention, as it can reverse several hallmarks of aging and extend lifespan in different animal models....