Help us: Donate
Follow us on:
×

Menu

Back

Month: May 2022

Crowd Funded Cures
We have written extensively about VitaDAO, a collective dedicated to community-governed, decentralized drug development. Probably the fastest and cheapest way to get geroprotective drugs to the market is by repurposing existing drugs, such as rapamycin, metformin, and acarbose. These drugs cost next to nothing, have a known safety record, and have shown a lot of...
Mouse feeding
In a new study published in Science, researchers show that caloric restriction and time-restricted feeding have an additive effect on lifespan in mice [1]. A well-known intervention Caloric restriction is considered the first intervention to reliably show that aging is a malleable phenomenon. The first trials were conducted on rats back in the 1930s and...
Fluorescent cells
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Yamanaka Factors and Partial Cellular ReprogrammingDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed...
BioAge logo
BioAge Labs is developing a class of compounds that have been shown to inhibit the NLRP3 protein, which has been linked to all-cause mortality, in mouse models and human cells. These compounds can be taken orally and cross the blood-brain barrier. The full press release is included here. RICHMOND, Calif.--(BUSINESS WIRE)-- BioAge Labs, Inc. (“BioAge”,...
Joao Pedro de Magalhaes
Professor João Pedro de Magalhães leads the Genomics of Ageing and Rejuvenation Lab at the Institute of Inflammation and Ageing in the University of Birmingham. He is also CSO of YouthBio Therapeutics, a US-based biotech company that develops rejuvenation gene therapies based on partial reprogramming by Yamanaka factors. Last year, he co-authored The hoverfly and...
Gene pill
In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of life-extending gene therapies from science fiction to reality. Why a cytomegalovirus? The human cytomegalovirus (CMV) is widely known as an endemic virus that, while usually...