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Tag: TGFβ1

Irina and Michael Conboy
June 16, 2020
Back in 2005, Drs. Irina and Michael Conboy showed that joining the circulatory systems of young and old mice together in a procedure called parabiosis could rejuvenate aged tissues and reverse some aspects of aging in old mice. Following this discovery, many researchers concluded that there must be something special in young blood that was...
Arthritic joint pain
May 19, 2020
Researchers have successfully reversed the course of osteoarthritis in rats by combining two molecules, one of which, a-Klotho, has long been a popular subject of anti-aging research. A classic age-related disease Osteoarthritis (OA) is a classic example of a wear-and-tear disease. Its manifestations are in the slow degeneration of articular cartilage, the appearance of bone...
Lab rat and flasks
May 11, 2020
Researchers have demonstrated that epigenetic age can be halved in rats by using signals commonly found in the blood. Epigenetic changes One of the proposed reasons we age are the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations. These alterations harm the fundamental functions of...
Irina and Michael Conboy
February 05, 2020
We were at the recent Longevity Therapeutics Conference in San Francisco, and we had the opportunity to interview Irina and Michael Conboy from UC Berkeley about their pioneering work on blood factors and aging. Irina is a member of our Scientific Advisory Board, and the Conboys' work is well-known to rejuvenation advocates, as they are...
August 26, 2018
For the August Journal Club, we took a look at a new paper that shows inhibiting TGFβ can boost liver regeneration [1]. We also discussed another related paper from 2015 by Conboy et al. which showed regeneration in aged mice was possible if TGFβ was inhibited [2]. Taken together, the two papers both confirm that systemic...
August 17, 2018
For the August edition of the Journal club, we will be taking a look at this new paper which focuses on boosting liver regeneration by inhibition of TGFβ1. We will be streaming the Journal Club live from our Facebook page. Setting liver regeneration free The liver is an excellent model of organ regeneration; however, regeneration may...