Tag: Small Molecules

Researchers have discovered a small molecule that effectively kills cancer cells in the most prevalent type of breast cancer. The new drug could help against cancer recurrence and decrease the need for surgery [1]. The ongoing fight against breast cancer Medicine has made great strides in treating breast cancer, but the fight is far from...

A team of Harvard researchers has published a paper in eLife detailing the downstream effects of small molecule partial cellular reprogramming. Rejuvenating cells from the ground up Yamanaka Factors - Opportunities for RejuvenationDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While...

A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. Beyond OSKM This paper begins with a discussion of the four well-known Yamanaka reprogramming factors (OSKM) that cause cells to revert to a previous epigenetic state, citing previous...