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Tag: Sirtuins

August 18, 2020
Scientists have shown that insulin-like growth factor (IGF-1) mitigates age-related mitochondrial decline and cellular aging in cultured smooth muscular cells [1], although other studies paint a grimmer picture of IGF-1's effects. Mitochondrial decline and aging Mitochondria, dubbed "the powerhouses of the cell" for producing the bulk of the energy that our cells need to operate,...
August 04, 2020
A group of scientists have shown that the SIRT2 protein increases the accumulation of amyloid beta, a known marker of Alzheimer's disease (AD), in the brains of mice. They propose a mechanism underlying this phenomenon and demonstrate that inhibiting SIRT2 ameliorates AD-associated cognitive decline in mice [1]. AD is one of the most devastating age-related...
July 28, 2020
A group of researchers has shown that yeast cells have two different and mutually exclusive modes of aging that seem to be interlinked. The scientists were also able to artificially induce a third mode of aging that prolongs both healthspan and lifespan. Yeast is a popular object of genomic research due to its short reproductive...
February 19, 2020
Researchers from Berkeley have established that SIRT2 prevents overactivation of the NLRP3 inflammasome through deacetylation. Targeting this pathway can possibly reduce or even reverse age-related chronic inflammation and insulin resistance. What are sirtuins? Sirtuins are a family of proteins that have long been a target of longevity research [1]. Sirtuins probably descend from some of...
August 01, 2019
The July Journal Club hosted by Dr. Oliver Medvedik looked at the recent SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity. The study took a deep dive into SIRT6 in multiple species and how it appears to support longevity to a lesser or greater...
April 24, 2019
Sirtuins have long been implicated in playing a role in the longevity of various species, including our own, and researchers at the University of Rochester have now discovered more supporting evidence that they do. What are sirtuins? Sirtuins are a family of proteins that facilitate cellular function and have long been known to play a...