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Tag: Sirtuins

February 19, 2020
Researchers from Berkeley have established that SIRT2 prevents overactivation of the NLRP3 inflammasome through deacetylation. Targeting this pathway can possibly reduce or even reverse age-related chronic inflammation and insulin resistance. What are sirtuins? Sirtuins are a family of proteins that have long been a target of longevity research [1]. Sirtuins probably descend from some of...
August 01, 2019
The July Journal Club hosted by Dr. Oliver Medvedik looked at the recent SIRT6 evolutionary biology paper by Dr. Vera Gorbunova and collaborators, showing a relationship between enhanced SIRT6 function and longevity. The study took a deep dive into SIRT6 in multiple species and how it appears to support longevity to a lesser or greater...
April 24, 2019
Sirtuins have long been implicated in playing a role in the longevity of various species, including our own, and researchers at the University of Rochester have now discovered more supporting evidence that they do. What are sirtuins? Sirtuins are a family of proteins that facilitate cellular function and have long been known to play a...
September 19, 2018
This month, we decided to do the Journal Club a bit earlier than usual to coincide with the launch of the NAD+ Mouse Project over at Lifespan.io. As the project is testing to see if NAD+ repletion increases lifespan, we thought that it would be an ideal time to explore NAD+ biology and take a...