Tag: Sirtuins

A paper published today in Nature Cardiovascular Research has explained a relationship between dilated cardiac myopathy (DCM), epigenetic dysregulation, NAD+, and the epigenetic regulatory molecule Kdm8. A gradual decline of ability DCM occurs when the left ventricle of the heart becomes enlarged and loses its ability to pump enough blood. The heart muscle gradually thins,...

In a new paper published in Nature, scientists have found that raising NAD+ levels via supplementation with nicotinamide mononucleotide (NMN) activates SIRT1 to dampen metastasis in mouse TNBC models [1]. A double-edged sword NAD+ is a ubiquitous co-enzyme that facilitates numerous processes in our body, from energy production to DNA repair. Its levels decline with...

A recent study published in Molecules has tested multiple thiazole-based derivatives that appear to activate the sirtuin SIRT1 more than resveratrol [1]. Sirtuins Resveratrol, commonly found in grape skins and red wine, generated some of the initial interest in sirtuin activators after initial studies showing many therapeutic benefits, such as cancer prevention [2]. Combined with...

What is NAD+? Nicotinamide adenine dinucleotide (NAD+) is a key coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base, and the other contains nicotinamide. NAD+ is essential for life, one of the most versatile molecules...

A study published in Aging has shown that the sirtuin SIRT6 has positive effects on multiple hallmarks of aging in the hearts of mice. Sirtuins Sirtuins are a family of proteins that have been shown to have significant effects on longevity in multiple model organisms. In a previous study, the sirtuin SIRT2 was shown to...

What is NMN? NMN is short for nicotinamide mononucleotide, a naturally occurring molecule present in all species. On the molecular level, it is a ribonucleotide, a basic structural unit of nucleic acid RNA. In form it consists of a nicotinamide group, a ribose and a phosphate group. It is a precursor molecule of the essential...