Help us: Donate
Follow us on:
×

Tag: AGEs

July 15, 2020
Two researchers, Alexander Fedintsev and Alexey Moskalev, have published an expansive review paper in which they propose a new hallmark of aging [1]. The authors draw our attention to a phenomenon that is sometimes overlooked in the context of aging: the accumulation of damage to long-lived molecules caused by the non-enzymatic chemical reactions of glycation,...
June 09, 2020
A group of Japanese scientists has found that advanced glycation end products (AGEs) tend to accumulate in osteoblasts with age, inducing apoptosis via endoplasmic reticulum stress. This mechanism likely contributes to the development of osteoporosis [1]. AGEs and age Advanced glycation end-products, fittingly abbreviated as AGEs, are proteins or lipids that have had sugars attached...
May 20, 2020
Researchers have demonstrated that age-related cognitive impairment and inflammation can be caused in young rats simply by giving them gut microbe populations from the guts of aged rats. The gut microbiome The microbiome describes the varied community of bacteria, archaea, eukarya, and viruses that inhabit our gut. The four bacterial phyla of Firmicutes, Bacteroidetes, Proteobacteria,...
January 09, 2020
There are lots of exciting companies working in the aging field, and it's a great time to tell you about three of the more interesting ones. Most of these companies are a while away from human trials yet, but their innovations could possibly be truly game changing. Underdog Pharma Underdog Pharmaceuticals is a spin-off company...
January 08, 2020
Some pleasant news has recently arrived: Revel Pharmaceuticals has successfully completed a seed round in order to begin developing therapeutics that target glucosepane crosslinks, which are a proposed reason why we age, develop diseases such as diabetes, and suffer from stiffened arteries and hypertension. In the business of startups, a seed round refers to a...
June 03, 2019
For the May Journal Club, Dr. Medvedik and guests took a look at the recent publication by the Spiegel Lab at Yale University where two forms of advanced glycation end products (AGEs) were successfully cleaved. We also covered this important breakthrough in our article – Reversal of Two Advanced Glycation End Products Achieved. Abstract Advanced glycation end products...