March 04, 2021
Every compound and aspect of biology has a dose-response relationship of some sort. Wildly different outcomes should be expected at different levels of a drug, different degrees of expression of a protein, differing activity of a signaling pathway. What is a beneficial therapy at one dose is a toxin at another. A great many toxic...
March 04, 2021
There is an increased interest in the mitochondrial permeability transition pore as a target for interventions that might improve mitochondrial function in aging. Mitochondria are the power plants of the cell, bacteria-like factories that package the chemical energy store molecule ATP via an energetic process of reactions. Mitochondria become dysfunction in aged tissues for reasons...
March 04, 2021
The measurement of biological rather than chronological age is a goal for many research groups. Numerous approaches are under development, and the levels of a wide variety of compounds in the blood have been found to vary with advancing age. The example here, neurofilament light chain, is just one of many. A robust biomarker of...
March 04, 2021
IMAGE: Matthew Foster, MD, and his UNC Lineberger colleagues have used an experimental safety switch incorporated as part of a chimeric antigen receptor-modified T cell therapy (CAR-T) for an aggressive form... view more Credit: UNC Lineberger Comprehensive Cancer Center CHAPEL HILL, North Carolina--UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated...
March 04, 2021
IMAGE: Dr. Ahmed Chadli view more view more Credit: Kim Ratliff, Augusta University photographerAUGUSTA, Ga. (March 4, 2021) - A compound isolated from a fungus growing on the roots of a flowering plant in Morocco shows promise as a powerful opponent of aggressive triple negative breast cancer, scientists say.They have early evidence that the peptide EnnA, isolated from...
March 04, 2021
IMAGE: Dr. Ahmed Chadli view more view more Credit: Kim Ratliff, Augusta University photographerAUGUSTA, Ga. (March 4, 2021) - A compound isolated from a fungus growing on the roots of a flowering plant in Morocco shows promise as a powerful opponent of aggressive triple negative breast cancer, scientists say.They have early evidence that the peptide EnnA, isolated from...
